2142-66-7

Basic information

• Product Name: 2-PHENYLBENZOYL METHIDE
• Synonyms: O-PHENYLACETOPHENONE;2-PHENYLHYPNONE;2-PHENYLBENZOYL METHIDE;2-PHENYLACETYLBENZENE;2-ACETYLBIPHENYL;1-[1,1'-BIPHENYL]-2-YLETHANONE;AKOS BAR-1584;1-(2-phenylphenyl)ethanone
• CAS NO: 2142-66-7
• Molecular Formula: C₁₄H₁₂O
• Molecular Weight: 195.24
• EINECS: 249-962-5
• Mol File: 2142-66-7.mol
• Article Data: 8

Chemical Properties

• Melting Point: 56-56.5 °C
• Boiling Point: 337.4 °C at 760 mmHg
• Flash Point: 146.1 °C
• Appearance: /
• Density: 1.053 g/cm³
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 2-PHENYLBENZOYL METHIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-PHENYLBENZOYL METHIDE(2142-66-7)
• EPA Substance Registry System: 2-PHENYLBENZOYL METHIDE(2142-66-7)

Safety Data

• Hazardous Substances Data: 2142-66-7(Hazardous Substances Data)

Usage

General Description

2-Phenylbenzoyl Methide is a chemical compound having a unique structure formed by an aromatic acid and an aromatic hydrocarbon derivative. As a complex organic compound, it is widely used in chemical and pharmaceutical industries due to its structural properties. 2-Phenylbenzoyl Methide is typically used as an intermediate in the production of various drugs and chemicals. Its distinctive compound structure makes it highly reactive, desired especially in chemical reactions involving cross-coupling and electrophilic substitution. Safety precautions are required while handling this compound due to its potential reactivity and toxicity.

Upstream product

• 2142-69-0 2-bromophenyl methyl ketone 
• 934-56-5 trimethyl(phenyl)stannane 
• 2234-16-4 1-(2,4-dichlorophenyl)ethan-1-one 
• 98-80-6 phenylboronic acid 
• 532-27-4 1-chloroacetophenone 
• 224311-51-7 johnphos 
• 595-90-4 tetraphenyltin(IV) 
• 2142-68-9 1-(2-chlorophenyl)ethanone 
• 36714-99-5 N-(1-(4-bromophenyl)ethylidene)-4-methoxybenzenamine 
• 100-58-3 phenylmagnesium bromide 
• 25201-35-8 2',3',4',5',6'-pentachloroacetophenone 
• 183313-79-3 2-(1-diazoethyl)-1,1'-biphenyl 

Downstream Products

• 104090-73-5 2-biphenylylacetothiomorpholide 
• 109472-71-1 Biphenylyl-⁽²⁾-glyoxal 
• 84-11-7 9,10-phenanthrenequinone 
• 12155-46-3 (C₆H₅C₆H₄COCH₃)Cr(CO)3 
• 12155-46-3 (C₆H₅C₆H₄COCH₃)Cr(CO)3 
• 1269207-24-0 2-(1-(biphenyl-2-yl)ethyl)benzo[d]thiazole 
• 1520098-09-2 (E)-1,2-di(biphenyl-2-yl)-1,2-dimethylethene 
• 486-25-9 9-fluorenone 

Relevant articles and documents

Polyoxometalate-based N-Heterocyclic Carbene (NHC) complexes for palladium-mediated C-C coupling and chloroaryl dehalogenation catalysis

Better together: A novel hybrid N-heterocyclic carbene (NHC) palladium complex, integrating a totally inorganic and polyanionic decatungstate unit, has been synthesized following a convergent strategy. The interplay of the Pd binding domains with the inorganic scaffold is instrumental in accessing multi-turnover catalysis in C-C crosscoupling and aromatic dehalogenation reactions under MW-assisted protocols (see scheme). (Figure Presented).

Iron-catalyzed chemoselective ortho arylation of aryl imines by directed C-H bond activation

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A catalytic and mechanistic investigation of a PCP pincer palladium complex in the Stille reaction

In an improved procedure, the complex {2,6-bis[(diphenylphosphino)methyl] benzene}chloropalladium(II) (1) was synthesised as its THF adduct and the structure was determined by X-ray crystallography. The catalytic properties of the derivative {2,6-bis[(diphenylphosphino)methyl]benzene}(trmuoroacetato) palladium(II) (2) was investigated in the Stille reaction. Complex 2 proves to be an excellent catalyst for the C-C cross-coupling between trimethyl phenyl stannane and aryl bromides using a very low catalyst loading (0.1-0.0001%), giving high turnover numbers (TONs) up to 6.9 × 105. A kinetic investigation of the catalytic reaction suggests a heterogeneous colloidal palladium catalyst formed from the PCP Pd(II) pre-catalyst. The Royal Society of Chemistry 2005.