214205-17-1

Upstream product

• 80077-71-0 diethyl (1,1-difluorobut-3-en-1-yl)phosphonate 
• 214205-16-0 dithiocarbonic acid S-[2-(2,4-difluoro-5-methyl-phenyl)-2-oxo-ethyl] ester O-ethyl ester 
• 452-76-6 2,4-difluorotoluene 
• 65094-22-6 diethyl (bromodifluoromethyl)phosphonate 
• 913073-68-4 2-chloro-1-(2,4-difluoro-5-methylphenyl)ethanone 

Downstream Products

• 214205-18-2 {2-[5-(2,4-difluoro-5-methyl-phenyl)-2,3-dihydro-thiophen-2-yl]-1,1-difluoro-ethyl}-phosphonic acid diethyl ester 

Relevant academic research and scientific papers

A divergent approach to highly substituted benzothiepinones and to 2,3-dihydrothieno[2,3-b]thiopyran-4-ones

The radical addition-transfer of S-(2-fluoro-phenacyl)xanthates can be used to construct rapidly benzothiepinones, including libraries of complex aza-bridged derivatives, and highly functionalized 2,3-dihydrothieno[2,3-b] thiopyran-4-ones.

An unusual and highly efficient access to thieno[2,3-b]-benzothiopyran structures

Dihydrothieno[2,3-b]-benzothiopyran-4-ones are easily obtained by an intermolecular radical addition to an unactivated olefin using an S-o- fluorophenacyl xanthate followed by a novel, base induced domino cyclisation.

An expedient radical based approach to difluorophosphonate analogues of thionucleosides

An expedient approach to difluorophosphonate analogues of thionucleosides of general structure 1 is described; the key step is a radical xanthate transfer chain reaction on diethyl 1,1-difluoro-3- butenylphosphonate.