913073-68-4

Upstream product

• 452-76-6 2,4-difluorotoluene 
• 79-04-9 chloroacetyl chloride 

Downstream Products

• 214205-17-1 [6-(2,4-difluoro-5-methyl-phenyl)-3-ethoxythiocarbonylsulfanyl-1,1-difluoro-6-oxo-hexyl]-phosphonic acid diethyl ester 
• 214205-18-2 {2-[5-(2,4-difluoro-5-methyl-phenyl)-2,3-dihydro-thiophen-2-yl]-1,1-difluoro-ethyl}-phosphonic acid diethyl ester 

Relevant academic research and scientific papers

An expedient radical based approach to difluorophosphonate analogues of thionucleosides

An expedient approach to difluorophosphonate analogues of thionucleosides of general structure 1 is described; the key step is a radical xanthate transfer chain reaction on diethyl 1,1-difluoro-3- butenylphosphonate.

A divergent approach to highly substituted benzothiepinones and to 2,3-dihydrothieno[2,3-b]thiopyran-4-ones

The radical addition-transfer of S-(2-fluoro-phenacyl)xanthates can be used to construct rapidly benzothiepinones, including libraries of complex aza-bridged derivatives, and highly functionalized 2,3-dihydrothieno[2,3-b] thiopyran-4-ones.

COMPOUNDS WHICH INHIBIT BETA-SECRETASE ACTIVITY AND METHODS OF USE THEREOF

The present invention provides novel beta-secretase inhibitors of the general formula (I), where the variables A1, A2, L1, L2, L3, R1, R2, R3, R4, R5, R6 and R7 are as defined in the claims, a method for their use in treating Alzheimer's disease, and methods for their use in reducing memapsin 2 catalytic activity.