214286-64-3

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 214286-62-1 (1'S,3R,5S)-5-(1'-azido-2'-methylpropyl)-3-(4''-fluorobenzyl)dihydrofuran-2-one 
• 799270-19-2 (4R,5S)-5-tert-Butoxycarbonylamino-4-hydroxy-6-methyl-heptanoic acid ethyl ester 
• 799270-20-5 (4S,5S)-5-tert-Butoxycarbonylamino-4-hydroxy-6-methyl-heptanoic acid ethyl ester 
• 799270-23-8 (4S,5S)-5-(2-Ethoxycarbonyl-ethyl)-4-isopropyl-2-oxo-oxazolidine-3-carboxylic acid tert-butyl ester 
• 214286-60-9 trans-(1'R,2S,2'R)-6-methyl-2-(4''-fluorobenzyl)hept-4-enoic acid (2'-hydroxy-1'-methyl-2-phenylethyl)methyl amide 
• 214286-61-0 (1'R,3R,5S)-5-(1'-bromo-2'-methylpropyl)-3-(4''-fluorobenzyl)dihydrofuran-2-one 
• 179617-47-1 trans-6-methyl-hept-4-enoic acid ethyl ester 
• 112375-59-4 trans-6-methylhept-4-enoic acid chloride 
• 61229-07-0 trans-6-methylhept-4-enoic acid 
• 799270-17-0 (4S,5S)-5-Dibenzylamino-4-hydroxy-6-methyl-hept-2-ynoic acid ethyl ester 
• 799270-21-6 (4R,5S)-5-tert-Butoxycarbonylamino-4-methanesulfonyloxy-6-methyl-heptanoic acid ethyl ester 
• 799270-22-7 3-((4S,5S)-4-Isopropyl-2-oxo-oxazolidin-5-yl)-propionic acid ethyl ester 
• 111060-54-9 N,N-dibenzylvalinol 

Downstream Products

• 799270-24-9 (S,E)-ethyl 4-((2R,5S)-5-(tert-butoxycarbonylamino)-2-(4-fluorobenzyl)-6-methyl-4-oxoheptanamido)-5-((S)-2-oxopyrrolidin-3-yl)pent-2-enoate 
• 223526-67-8 (2R,5S)-5-(tert-butoxycarbonylamino)-2-(4-fluorobenzyl)-6-methyl-4-oxoheptanic acid 

Relevant academic research and scientific papers

An efficient and tunable route to AG7088, a rhinovirus protease inhibitor

Aldol reaction of N,N-dibenzyl valinal with propiolic acid ethyl ester derived lithium reagent provides anti-aminoalcohol 8 and syn-aminoalcohol 9, which are converted into the lactone 6 via two different routes. Alkylation of 6 followed by lactone ring o

Structure-based design, synthesis, and biological evaluation of irreversible human rhinovirus 3C protease inhibitors. 3. Structure-activity studies of ketomethylene-containing peptidomimetics

The structure-based design, chemical synthesis, and biological evaluation of various ketomethylene-containing human rhinovirus (HRV) 3C protease (3CP) inhibitors are described. These compounds are comprised of a peptidomimetic binding determinant and an e