2143-98-8Relevant academic research and scientific papers
Discovery of Unprecedented Hydrazine-Forming Machinery in Bacteria
Matsuda, Kenichi,Tomita, Takeo,Shin-Ya, Kazuo,Wakimoto, Toshiyuki,Kuzuyama, Tomohisa,Nishiyama, Makoto
, p. 9083 - 9086 (2018)
Recent studies described several different routes that facilitate nitrogen-nitrogen bond formation in natural product biosynthesis. We report herein the identification of unprecedented machinery for hydrazine formation involved in the biosynthesis of s56-p1, a dipeptide natural product with a unique hydrazone unit. The gene cassette comprising this machinery is widespread across several bacterial phyla, highlighting the overlooked potential of bacteria to synthesize hydrazine.
Azine based AIEgens with multi-stimuli response towards picric acid
Pavithra, Kumaravelu,Sathiyaraj, Munusamy,Thiagarajan, Viruthachalam
, p. 8402 - 8411 (2020)
Multifunctional aggregation induced emission luminogens (AIEgens) are novel materials which have significant applications in various fields including biomedical, optoelectronics and sensors. Enormous efforts have been directed towards the strategic development and characterisation of AIEgens, in order to better understand the AIE mechanism. Herein, we studied the photophysical properties of symmetrical azine (D-π-D) based AIEgens in detail by varying the solvent polarity and viscosity. The AIE behaviour of the azine derivatives relies on the substituents on the nitrogen atom of the amine moiety. Further, these azine derivatives sense the picric acid (PA) with high selectivity and sensitivity in both monomer and aggregated forms. The hydrogen bonding interaction of PA with any one side of the amine nitrogen leads to the formation of a new intramolecular charge transfer state which results in the formation of new absorption and emission spectra. Interestingly in the presence of PA, azine monomers exhibit fluorescence enhancement in pure THF, while aggregated azine molecules show fluorescence quenching in THF-water mixtures.
Tuning of azine derivatives for selective recognition of Ag+ with the in vitro tracking of endophytic bacteria in rice root tissue
Ghosh, Abhijit,Adhikari, Sangita,Ta, Sabyasachi,Banik, Avishek,Dangar, Tushar Kanti,Mukhopadhyay, Subhra Kanti,Matalobos, Jesús Sanmartín,Brand?o, Paula,Félix, Vítor,Das, Debasis
, p. 19491 - 19499 (2016)
Several azine derivatives have been prepared and structurally characterized by spectroscopic and single-crystal X-ray diffraction analysis. Two of them, viz. naphthalene based (A10) and anthracene based (A11) show fluorescence enhancement in the presence of Ag+ in aqueous-methanol. Moreover, A11 efficiently tracks Ag+in vitro endophytic bacteria infected rice root tissue. Experimental results have been substantiated by theoretical DFT calculations.
Conversion of Ammonia to Hydrazine Induced by High-Frequency Ultrasound
Allavena, Audrey,Amaniampong, Prince N.,Chave, Tony,De Oliveira Vigier, Karine,Grimaud, Laurie,Humblot, Anaelle,Jér?me, Fran?ois,Streiff, Stéphane
supporting information, p. 25230 - 25234 (2021/09/14)
Hydrazine is a chemical of utmost importance in our society, either for organic synthesis or energy use. The direct conversion of NH3 to hydrazine is highly appealing, but it remains a very difficult task because the degradation of hydrazine is thermodynamically more feasible than the cleavage of the N?H bond of NH3. As a result, any catalyst capable of activating NH3 will thus unavoidably decompose N2H4. Here we show that cavitation bubbles, created by ultrasonic irradiation of aqueous NH3 at a high frequency, act as microreactors to activate and convert NH3 to NH species, without assistance of any catalyst, yielding hydrazine at the bubble–liquid interface. The compartmentation of in-situ-produced hydrazine in the bulk solution, which is maintained close to 30 °C, advantageously prevents its thermal degradation, a recurrent problem faced by previous technologies. This work also points towards a path to scavenge .OH radicals by adjusting the NH3 concentration.
Dihydrazone compound high in affinity with Abeta protein and Tau protein, derivative thereof, and applications of dihydrazone compound and derivative
-
Paragraph 0029-0031; 0050-0052, (2019/05/15)
The invention provides a dihydrazone compound high in affinity with Abeta protein and Tau protein, a derivative thereof, and applications of the dihydrazone compound and the derivative. The structureof the dihydrazone compound is represented by formula I. The dihydrazone compound can be directly taken as a fluorescence probe used for detecting neurofibrillary tangles in vivo or in tissue samples;when the dihydrazone compound is adopted in nuclear medicine imaging, appropriate radioisotopes are needed for labeling. The dihydrazone compound is especially suitable to be used for diagnosis of neurodegenerative diseases, and diagnosis of patients with diseases with Abeta plaques including Alzheimer's disease.
C[sbnd]N bond formation in alicyclic and heterocyclic compounds by amine-modified nanoclay
Zarnegar, Zohre,Alizadeh, Roghayeh,Ahmadzadeh, Majid,Safari, Javad
, p. 58 - 65 (2017/05/12)
In the current protocol, amine functionalized montmorillonite K10 nanoclay (NH2-MMT) was applied to catalyze the formation of C[sbnd]N bonds in the synthesis of azines and 2-aminothiazoles at room temperature. In comparison with the current methods of C[sbnd]N bond formation, this approach displays specific advantages include atom economy, clean conversion, design for energy efficiency, the use of nontoxic and heterogeneous catalyst, higher purity and yields, safer solvent and reagents for this organic transformation.
Compound capable of detecting organophosphate neurotoxic agent stimulants and application thereof
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Paragraph 0033; 0039; 0040; 0041; 0042; 0043, (2017/03/08)
The invention relates to a compound capable of detecting an organophosphate neurotoxic agent stimulants and application thereof. The compound has a structural general formula shown as the specification, can be used for detection of organophosphate neurotoxic agent stimulants according to the change of color or fluorescence in preparation of solutions, films or test paper. The compound provided by the invention has the advantages of simple preparation method, high yield, easy separation, high purity, and sensitive response to organophosphorus neurotoxic agents, and can achieve quick and accurate detection of organophosphorus neurotoxic agent stimulants in solutions or gas phases.
Tungsten hexachloride nanoparticles loaded on montmorillonite K-10: a novel solid acid catalyst in the synthesis of symmetrical and unsymmetrical azines
Safari, Javad,Gandomi-Ravandi, Soheila,Shariat, Saeedeh
, p. 1499 - 1507 (2016/07/06)
In the present investigation, we have developed a novel technique to prepare azines using nano-WCl6 loaded on Montmorillonite K10 clay as a highly active catalyst. A variety of aldehydes and ketones were efficiently converted to the corresponding azines using catalytic amounts of nanosized WCl6/Mont. K10 under mild conditions. The nanostructures of WCl6 loaded on Mont. K10 as solid acid catalyst have been prepared by solid dispersion method. The advantages of this catalyst are rapid completion of the reactions, simplicity of performance, lack of pollution and mild and green reaction conditions. The morphologies, structure, and chemical components of parent and modified clay were successfully characterized using SEM, FT-IR, CV, XRD and EDX measurements.
Anomalous reaction of hydrazine hydrate with 5-arylidene barbiturates: Formation of benzalazines
Goudgaon,Upendar Reddy, Ch.,Patil, Sharanabasappa,Sheshikant
, p. 277 - 282 (2019/01/21)
Reaction of 5-arylidene barbiturates (3a-i) with hydrazine hydrate resulted in the unusual formation of novel benzalazines (5a-i) in 70-90% yield rather than the expected pyrazole fused pyrimidines.
Features of the reactions of β-Aryl(heteryl)-α-nitroacrylates with N,N-, N,O-, and N,S-Binucleophiles
Baichurina,Baichurin,Filippenko,Aboskalova,Berestovitskaya
, p. 1400 - 1408 (2013/01/15)
The reactions of β-aryl(heteryl)-α-nitroacrylates with N,N-, N,O-, and N,S-binucleophiles proceed regiospecifically through the initial formation of the AdN products, among which only the product from oaminothiophenol was isolated. The conditions of converting the S-adducts into 2-aryl(heteryl)benzothiazole were found. The N-adducts formed in the reaction with hydrazine, o-phenylenediamine, and o-aminophenol undergo immediately the spontaneous transformation into the linear (azine, azomethine) or heterocyclic (benzimidazole) structures. Pleiades Publishing, Ltd., 2012.
