214345-66-1

Upstream product

• 214345-64-9 tert-Butyl-[2-((4S,6S)-6-furan-2-yl-2,2-dimethyl-[1,3]dioxan-4-yl)-ethoxy]-diphenyl-silane 
• 112497-18-4 (4R,6S)-6-Benzyloxymethyl-2,2-dimethyl-[1,3]dioxane-4-carbaldehyde 
• 112497-17-3 (4S,6S)-6-Benzyloxymethyl-2,2-dimethyl-[1,3]dioxane-4-carbaldehyde 
• 112497-21-9 (4S,6S)-6-<(benzyloxy)methyl>-4-(2-hydroxyethyl)-2,2-dimethyl-1,3-dioxacyclohexane 
• 214345-63-8 6-((S)-2-(furan-2-yl)-2-hydroxyethyl)-2,2-dimethyl-4H-1,3-dioxin-4-one 
• 18107-18-1 diazomethyl-trimethyl-silane 
• 112497-22-0 (3S,5S)-6-<(benzyloxy)methyl>-4-<1-(tert-butyldiphenylsilyloxy)ethyl>-2,2-dimethyl-1,3-dioxacyclohexane 
• 112497-15-1 (1S,3S)-4-Benzyloxy-3-(tert-butyl-dimethyl-silanyloxy)-1-[1,3]dithian-2-yl-butan-1-ol 
• 112497-16-2 (4S,6S)-4-Benzyloxymethyl-6-[1,3]dithian-2-yl-2,2-dimethyl-[1,3]dioxane 
• 112497-20-8 (4S,6R)-4-Benzyloxymethyl-2,2-dimethyl-6-vinyl-[1,3]dioxane 

Downstream Products

• 112497-23-1 Trifluoro-methanesulfonic acid (4S,6S)-6-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-2,2-dimethyl-[1,3]dioxan-4-ylmethyl ester 
• 1067185-71-0 (4S,6S)-6-(2-(tert-butyldiphenylsilyloxy)ethyl)-2,2-dimethyl-1,3-dioxane-4-carbaldehyde 
• 112497-24-2 (S)-((4R,6S)-6-Benzyloxymethyl-2,2-dimethyl-[1,3]dioxan-4-yl)-(2-{(4S,6S)-6-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-2,2-dimethyl-[1,3]dioxan-4-ylmethyl}-[1,3]dithian-2-yl)-methanol 
• 214345-67-2 tert-Butyl-[2-((4S,6S)-6-ethynyl-2,2-dimethyl-[1,3]dioxan-4-yl)-ethoxy]-diphenyl-silane 

Relevant academic research and scientific papers

A first convergent synthesis of the polyolic fragment of the antifungal pentaene macrolide strevertene A

The C(4-14) polyolic segment of antifungal macrolide strevertenes has been synthesized for the first time in protected form, incorporating four stereogenic centers. The synthetic strategy developed is based on the connection of two subunits prepared start

Convergent synthesis of the amphotericin polyol subunit employing asymmetric dienolate addition reactions

We have described a convergent asymmetric synthesis of the polyol fragment of amphotericin B that utilizes a versatile dienolate aldol addition reaction of furfural to rapidly assemble the constituent polyol subunit. This strategy allows for the efficient synthesis of large quantities of the desired fragment while being inherently flexible to allow the construction of analogs. The synthesis of the C1-C13 fragment of amphotericin requires only eleven steps and proceeds in 28% overall yield.