214532-99-7

Upstream product

• 214532-98-6 methyl (2E,5R)-6-(tert-butyldiphenylsilyloxy)-5-methyl-2-hexenoate 
• 157158-35-5 methyl (2E,5R)-6-(tert-butyldiphenylsilyloxy)-5-methyl-2-hexen-1-ol 
• 186641-76-9 (2R)-1-(tert-butyldiphenylsilyloxy)-3-cyano-2-methylpropane 
• 186641-79-2 (R)-4-((tert-Butyldiphenylsilyl)oxy)-3-methylbutanal 
• 58479-61-1 tert-butylchlorodiphenylsilane 
• 136786-35-1 (2S)-1-(tert-butyldiphenylsilyloxy)-2-methyl-3-(toluenesulfonyloxy)propane 
• 95514-03-7 (S)-3-(tert-butyl-diphenyl-silanyloxy)-2-methyl-propionic acid methyl ester 
• 95514-04-8 (R)-3-(tert-butyldiphenylsilyloxy)-2-methylpropan-1-ol 
• 214542-23-1 (2S,3S,5R)-6-(tert-butyldiphenylsilyloxy)-2,3-epoxy-5-methyl-1-hexanol 

Downstream Products

• 214533-28-5 (2R,4S,5S,6R,7R,8S,12R,14R,17S,20R)-5,7-bis(tert-butyldimethylsilyloxy)-1,2-isopropylidenedioxy-14-(4-methoxybenzyloxy)-6,12-dimethyl-11,18-dimethylidene-10-oxo-21-<2-(trimethylsilyl)ethoxymethoxy>-4,8; 17,20-diepoxyhenicosane 
• 201336-82-5 (2R,4S,5S,6R,7R,8S,10S,12R,14R,17S,20R)-5,7-bis(tert-butyldimethylsilyloxy)-1,2-isopropylidenedioxy-14-(4-methoxybenzyloxy)-6,12-dimethyl-11,18-dimethylidene-21-<2-(trimethylsilyl)ethoxymethoxy>-4,8; 17,20-diepoxyhenicosan-10-ol 
• 201336-84-7 (2R,4S,5S,6R,7R,8S,10R,12R,14R,17S,20R)-5,7-bis(tert-butyldimethylsilyloxy)-1,2-isopropylidenedioxy-14-(4-methoxybenzyloxy)-6,12-dimethyl-11,18-dimethylidene-21-<2-(trimethylsilyl)ethoxymethoxy>-4,8; 17,20-diepoxyhenicosan-10-ol 
• 214533-40-1 (2R,4S,5S,6R,7R,8S,10R,12R,14R,17S,20R)-5,7-bis(tert-butyldimethylsilyloxy)-1,2-isopropylidenedioxy-14-(4-methoxybenzyloxy)-6,12-dimethyl-11,18-dimethylidene-21-<2-(trimethylsilyl)ethoxymethoxy>-10-trimethylsilyloxy-4,8; 17,20-diepoxyhenicosane 
• 214533-29-6 C₅₇H₁₀₆O₁₁Si₄ 
• 201336-81-4 (2R,4S,5S,6R,7R,8S,10S,11R,12R,14R,17S,20R)-5,7-bis(tert-butyldimethylsilyloxy)-6,12-dimethyl-10-hydroxy-1,2-isopropylidenedioxy-14-(4-methoxybenzyloxy)-11-methoxycarbonyl-18-methylidene-21-<2-(trimethylsilyl)ethoxymethoxy>-4,8; 17,20-diepoxyhenicosane 
• 157240-52-3 methyl (3R,5R)-7-<(2S,5R)-3-methylidene-5-(2-(trimethylsilyl)ethoxymethoxymethyl)tetrahydrofuryl>-5-(4-methoxybenzyloxy)-5-methylheptanoate 
• 214533-09-2 (3S,5R)-6-(tert-butyldiphenylsilyloxy)-3-(4-methoxybenzyloxy)-5-methylhexanal 
• 214533-00-3 (3S,5R)-6-(tert-butyldiphenylsilyloxy)-3-(4-methoxybenzyloxy)-5-methyl-1-hexenol 
• 214533-16-1 (2S,5R)-2-<(3R,5R)-6-hydroxy-3-(4-methoxybenzyloxy)-5-methylhexyl>-5-benzoyloxymethyl-3-(methylidene)tetrahydrofuran 
• 214533-18-3 (3R,5R)-7-<(2S,5R)-5-benzoyloxymethyl-3-(methylidene)tetrahydrofuryl>-5-(4-methoxybenzyloxy)-3-methylheptanenitrile 
• 214533-20-7 (2S,5R)-2-<(3R,5R)-6-formyl-3-(4-methoxybenzyloxy)-5-methylhexyl>-3-methylidene-5-<2-(trimethylsilyl)ethoxymethoxymethyl>tetrahydrofuran 
• 214533-19-4 (2S,5R)-2-<(3R,5R)-6-cyano-3-(4-methoxybenzyloxy)-5-methylhexyl>-3-methylidene-5-<2-(trimethylsilyl)ethoxymethoxymethyl>tetrahydrofuran 
• 214533-12-7 (2S,3S,5R)-2-<(1E,3S,5R)-6-(tert-butyldiphenylsilyloxy)-3-(4-methoxybenzyloxy)-5-methy-1-hexenyl>-5-(hydroxymethyl)tetrahydrofuran-3-ol 

Relevant academic research and scientific papers

Synthetic studies on halichondrin B, an antitumor polyether macrolide isolated from a marine sponge. 9. Synthesis of the C16 - C36 unit via stereoselective construction of the D and E rings

The C16 - C36 unit of halichondrin B was stereoselectively synthesized via the aldol condensation of two C16 - C26 esters with the previously synthesized C27 - C36 aldehyde followed by E ring construction. The C16 - C26 esters were prepared starting from (2S)-3-hydroxy-2-methylpropionic acid and L-tartaric acid via construction of the D ring by iodoetherification.