214533-11-6Relevant articles and documents
Synthetic studies on halichondrin B, an antitumor polyether macrolide isolated from a marine sponge. 9. Synthesis of the C16 - C36 unit via stereoselective construction of the D and E rings
Horita, Kiyoshi,Nagasawa, Masaaki,Sakurai, Youji,Yonemitsu, Osamu
, p. 1199 - 1216 (2007/10/03)
The C16 - C36 unit of halichondrin B was stereoselectively synthesized via the aldol condensation of two C16 - C26 esters with the previously synthesized C27 - C36 aldehyde followed by E ring construction. The C16 - C26 esters were prepared starting from (2S)-3-hydroxy-2-methylpropionic acid and L-tartaric acid via construction of the D ring by iodoetherification.