214533-18-3

Upstream product

• 214533-15-0 (2S,5R)-2-<(3R,5R)-6-(tert-butyldiphenylsilyloxy)-3-(4-methoxybenzyloxy)-5-methylhexyl>-5-benzoyloxymethyl-3-(methylidene)tetrahydrofuran 
• 214533-81-0 (2S,3S,5R)-2-<(3R,5R)-6-(tert-butyldiphenylsilyloxy)-3-(4-methoxybenzyloxy)-5-methyhexyl>-5-(benzoyloxymethyl)tetrahydrofuran-3-ol 
• 214533-14-9 (2S,5R)-5-(benzoyloxymethyl)-2-<(3R,5R)-6-(tert-butyldiphenylsilyloxy)-3-(4-methoxybenzyloxy)-5-methyhexyl>tetrahydrofuran-3-one 
• 157240-51-2 (2R,3S,5R)-2-<(1S,3S,5R)-6-(tert-butyldiphenylsilyloxy)-1-iodo-3-(4-methoxybenzyloxy)-5-methylhexyl>-5-(hydroxymethyl)tetrahydrofuran-3-ol 
• 214533-11-6 (5E,2R,4S,8R,10R)-11-(tert-butyldiphenylsilyloxy)-1,2-isopropylidenedioxy-8-(4-methoxybenzyloxy)-10-methyl-5-undecen-4-ol 
• 157240-49-8 (5E,2R,4S,8R,10R)-11-(tert-butyldiphenylsilyloxy)-8-(4-methoxybenzyloxy)-10-methyl-5-undecene-1,2,4-triol 
• 214533-10-5 (5E,2R,8R,10R)-11-(tert-butyldiphenylsilyloxy)-1,2-isopropylidenedioxy-8-(4-methoxybenzyloxy)-10-methyl-5-undecen-4-one 
• 214533-13-8 (2S,3S,5R)-2-<(3R,5R)-6-(tert-butyldiphenylsilyloxy)-3-(4-methoxybenzyloxy)-5-methyhexyl>-5-(hydroxymethyl)tetrahydrofuran-3-ol 
• 214533-12-7 (2S,3S,5R)-2-<(1E,3S,5R)-6-(tert-butyldiphenylsilyloxy)-3-(4-methoxybenzyloxy)-5-methy-1-hexenyl>-5-(hydroxymethyl)tetrahydrofuran-3-ol 
• 214533-16-1 (2S,5R)-2-<(3R,5R)-6-hydroxy-3-(4-methoxybenzyloxy)-5-methylhexyl>-5-benzoyloxymethyl-3-(methylidene)tetrahydrofuran 
• 214533-00-3 (3S,5R)-6-(tert-butyldiphenylsilyloxy)-3-(4-methoxybenzyloxy)-5-methyl-1-hexenol 
• 214533-09-2 (3S,5R)-6-(tert-butyldiphenylsilyloxy)-3-(4-methoxybenzyloxy)-5-methylhexanal 
• 214532-99-7 (3S,5R)-6-(tert-butyldiphenylsilyloxy)-5-methylhexane-1,3-diol 
• 214542-23-1 (2S,3S,5R)-6-(tert-butyldiphenylsilyloxy)-2,3-epoxy-5-methyl-1-hexanol 

Downstream Products

• 214533-22-9 (2R,4S,5S,6R,7R,8S,10S,11S,12R,14R,17S,20R)-5,7-bis(tert-butyldimethylsilyloxy)-1,2-isopropylidenedioxy-14-(4-methoxybenzyloxy)-6,12-dimethyl-18-methylidene-11-toluenesulfonyloxymethyl-21-<2-(trimethylsilyl)ethoxymethoxy>-4,8; 17,20-diepoxyhenicosan-... 
• 214533-21-8 (2R,4S,5S,6R,7R,8S,10S,11R,12R,14R,17S,20R)-5,7-bis(tert-butyldimethylsilyloxy)-11-hydroxymethyl-1,2-isopropylidenedioxy-14-(4-methoxybenzyloxy)-6,12-dimethyl-18-methylidene-21-<2-(trimethylsilyl)ethoxymethoxy>-4,8;17,20-diepoxyhenicosan-10-ol 
• 214533-33-2 benzoic acid 5-(2-{6-[3,5-bis-(tert-butyl-dimethyl-silanyloxy)-6-(2,2-dimethyl-[1,3]dioxolan-4-ylmethyl)-4-methyl-tetrahydro-pyran-2-ylmethyl]-4-methyl-5-methylene-tetrahydro-pyran-2-yl}-ethyl)-4-methylene-tetrahydro-furan-2-ylmethyl ester 
• 214532-97-5 (2R,4S,5S,6R,7R,8S,10R,12R,14S,17S,20R)-21-benzoyloxy-1,2-isopropylidenedioxy-6-methyl-11,18-dimethylidene-4,8; 10,14; 17,20-triepoxyhenicosane-5,7-diol 
• 214533-19-4 (2S,5R)-2-<(3R,5R)-6-cyano-3-(4-methoxybenzyloxy)-5-methylhexyl>-3-methylidene-5-<2-(trimethylsilyl)ethoxymethoxymethyl>tetrahydrofuran 
• 214533-20-7 (2S,5R)-2-<(3R,5R)-6-formyl-3-(4-methoxybenzyloxy)-5-methylhexyl>-3-methylidene-5-<2-(trimethylsilyl)ethoxymethoxymethyl>tetrahydrofuran 
• 157240-52-3 methyl (3R,5R)-7-<(2S,5R)-3-methylidene-5-(2-(trimethylsilyl)ethoxymethoxymethyl)tetrahydrofuryl>-5-(4-methoxybenzyloxy)-5-methylheptanoate 
• 201336-81-4 (2R,4S,5S,6R,7R,8S,10S,11R,12R,14R,17S,20R)-5,7-bis(tert-butyldimethylsilyloxy)-6,12-dimethyl-10-hydroxy-1,2-isopropylidenedioxy-14-(4-methoxybenzyloxy)-11-methoxycarbonyl-18-methylidene-21-<2-(trimethylsilyl)ethoxymethoxy>-4,8; 17,20-diepoxyhenicosane 
• 214533-29-6 C₅₇H₁₀₆O₁₁Si₄ 
• 214533-40-1 (2R,4S,5S,6R,7R,8S,10R,12R,14R,17S,20R)-5,7-bis(tert-butyldimethylsilyloxy)-1,2-isopropylidenedioxy-14-(4-methoxybenzyloxy)-6,12-dimethyl-11,18-dimethylidene-21-<2-(trimethylsilyl)ethoxymethoxy>-10-trimethylsilyloxy-4,8; 17,20-diepoxyhenicosane 
• 201336-84-7 (2R,4S,5S,6R,7R,8S,10R,12R,14R,17S,20R)-5,7-bis(tert-butyldimethylsilyloxy)-1,2-isopropylidenedioxy-14-(4-methoxybenzyloxy)-6,12-dimethyl-11,18-dimethylidene-21-<2-(trimethylsilyl)ethoxymethoxy>-4,8; 17,20-diepoxyhenicosan-10-ol 
• 201336-82-5 (2R,4S,5S,6R,7R,8S,10S,12R,14R,17S,20R)-5,7-bis(tert-butyldimethylsilyloxy)-1,2-isopropylidenedioxy-14-(4-methoxybenzyloxy)-6,12-dimethyl-11,18-dimethylidene-21-<2-(trimethylsilyl)ethoxymethoxy>-4,8; 17,20-diepoxyhenicosan-10-ol 
• 214533-28-5 (2R,4S,5S,6R,7R,8S,12R,14R,17S,20R)-5,7-bis(tert-butyldimethylsilyloxy)-1,2-isopropylidenedioxy-14-(4-methoxybenzyloxy)-6,12-dimethyl-11,18-dimethylidene-10-oxo-21-<2-(trimethylsilyl)ethoxymethoxy>-4,8; 17,20-diepoxyhenicosane 

Relevant academic research and scientific papers

Synthetic studies on halichondrin B, an antitumor polyether macrolide isolated from a marine sponge. 9. Synthesis of the C16 - C36 unit via stereoselective construction of the D and E rings

The C16 - C36 unit of halichondrin B was stereoselectively synthesized via the aldol condensation of two C16 - C26 esters with the previously synthesized C27 - C36 aldehyde followed by E ring construction. The C16 - C26 esters were prepared starting from (2S)-3-hydroxy-2-methylpropionic acid and L-tartaric acid via construction of the D ring by iodoetherification.