21455-97-0Relevant academic research and scientific papers
Enantioselective biotransformation of α,α-disubstituted dinitriles to the corresponding 2-cyanoacetamides using Rhodococcus sp. CGMCC 0497
Wu, Zhong-Liu,Li, Zu-Yi
, p. 2133 - 2142 (2007/10/03)
A new application of nitrile-converting enzymes in the synthesis of optically active α,α-disubstituted-α-cyanoacetamides from α,α-disubstituted-malononitriles with whole cells of Rhodococcus sp. CGMCC 0497 is described. The products were obtained with enantiomeric excesses of up to >99%, and yields of up to 53%. They are very useful chiral intermediates especially for the synthesis of chiral α,α-disubstituted amino acids but have never been synthesized directly by chemical or enzymatic methods.
Phase Transfer Catalysis without Solvent: Selective Mono- or Di-alkylation of Malononitrile
Diez-Barra, Enrique,Hoz, Antonio de la,Moreno, Andres,Sanchez-Verdu, Prado
, p. 2589 - 2592 (2007/10/02)
Monoalkyl and symmetrical or unsymmetrical dialkylmalononitriles have been prepared selectively by phase transfer catalysis in the absence of solvent.Exclusive formation of a particular compound is achieved in all cases except for benzylmalononitrile 2f (79percent) and prop-2-ynylmalononitrile 2g (62percent).
