214550-86-4

Upstream product

• 58479-61-1 tert-butylchlorodiphenylsilane 
• 155742-48-6 4-hydroxymethyl-1,3-oxazole 

Downstream Products

• 214550-89-7 [4-(tert-Butyl-diphenyl-silanyloxymethyl)-oxazol-2-yl]-oxazol-5-yl-methanol 
• 916810-62-3 4-({[(1,1-dimethylethyl)(diphenyl)silyl]oxy}methyl)-2-(4-fluorophenyl)-1,3-oxazole 

Relevant academic research and scientific papers

Chemical Compounds

This invention relates to non-steroidal compounds that are modulators of androgen, glucocorticoid, mineralocorticoid, and progesterone receptors, and also to the methods for the making and use of such compounds.

Synthetic studies on bengazoles of marine sponge origin. Synthesis of the core bis-oxazole fragments

The core bis-oxazole fragment 3 was constructed by the coupling of the aldehyde (6) with the lithiated oxazoles (7), oxidation of the resulting bis-oxazolyl methanol (11), followed by the asymmetric reduction with (R)-(+)-BINAL-H as key steps. Preparation of another bis-oxazole fragment (4) was accomplished by the Barton-McCombie radical deoxygenation reaction of 11.