214550-89-7Relevant articles and documents
Synthetic studies on bengazoles of marine sponge origin. Synthesis of the core bis-oxazole fragments
Chittari, Pabba,Hamada, Yasumasa,Shioiri, Takayuki
, p. 1022 - 1024 (1998)
The core bis-oxazole fragment 3 was constructed by the coupling of the aldehyde (6) with the lithiated oxazoles (7), oxidation of the resulting bis-oxazolyl methanol (11), followed by the asymmetric reduction with (R)-(+)-BINAL-H as key steps. Preparation of another bis-oxazole fragment (4) was accomplished by the Barton-McCombie radical deoxygenation reaction of 11.