214628-89-4Relevant academic research and scientific papers
FARNESOID X RECEPTOR AGONISTS AND USES THEREOF
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, (2017/04/11)
Described herein are compounds that are farnesoid X receptor agonists, methods of making such compounds, pharmaceutical compositions and medicaments comprising such compounds, and methods of using such compounds in the treatment of conditions, diseases, o
Structural modifications of 6-naphthalene-2-carboxylate retinoids
Yu, Kuo-Long,Ostrowski, Jacek,Chen, Simon,Tramposch, Kenneth M.,Reczek, Peter R.,Mansuri, Muzammil M.,Starrett Jr., John E.
, p. 2865 - 2870 (2007/10/03)
The keto linker of 2-naphthoate retinoid 1 has been found nonessential for RAR transactivation activity and can be replaced with heteroatoms such as S, O, N without significant reduction of the activity. On the other hand, substitutions on the aromatic rings of retinoids 1 and 2 resulted in analogs with reduced potentcy and RAR selectivity.
