21469-78-3

Basic information

• Product Name: (E)-3-(2-chlorophenyl)-N, N-dimethylacrylamide
• Synonyms: (E)-3-(2-chlorophenyl)-N, N-dimethylacrylamide
• CAS NO: 21469-78-3
• Molecular Weight: 209.675
• Mol File: 21469-78-3.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: (E)-3-(2-chlorophenyl)-N, N-dimethylacrylamide(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-3-(2-chlorophenyl)-N, N-dimethylacrylamide(21469-78-3)
• EPA Substance Registry System: (E)-3-(2-chlorophenyl)-N, N-dimethylacrylamide(21469-78-3)

Safety Data

• Hazardous Substances Data: 21469-78-3(Hazardous Substances Data)

Upstream product

• 137-26-8 Thiram 
• 704-96-1 trans-2-chlorocinnamic acid 
• 127-19-5 N,N-dimethyl acetamide 
• 68-12-2 N,N-dimethyl-formamide 
• 89-98-5 2-chloro-benzaldehyde 

Relevant articles and documents

Cu(II)-Mediated keto C(sp3)-H bond α-acyloxylation of N, N-dialkylamides with aromatic carboxylic acids

The selective oxidative coupling of aromatic carboxylic acids with the C(sp3)-H bond adjacent to the keto group of alkylamides has been developed by employing a low cost copper source. This provides an efficient approach for synthesis of O-benzoylglycolamides. The protocol displayed good functional group tolerance. A broad range of benzoic acids directly coupled with alkylamides to afford a variety of O-benzoylglycolamides in moderate to good yields. In addition, a reasonable radical mechanism was proposed based on EPR experiments.

Preparation method of cinnamamide (by machine translation)

The synthesis system disclosed by the invention has the advantages of simple :(1) reaction conditions, wide, reaction conditions, reaction conditions, wide ;(2) substrate range, high yield (1) and wide application range, and the reaction liquid, can be used as an anti-cancer drug, anti-anti-tumor and spice precursor compound in an organic solvent to prepare a corresponding cinnamide compound, product cinnamide . The synthesis system disclosed by the invention has a broad spectrum . The synthesis system disclosed by the invention has a broad spectrum of biological activity, and is suitable for popularization and application, in the following steps, synthesizing cinnamic acid and thiuram disulfide as a raw material, in an organic, solvent, and purifying, parts by mass, separation and purification of the obtained reaction, solution in an organic solvent. (by machine translation)

Aldol condensation of amides using phosphazene-based catalysis

We have developed a new method for the direct aldol condensation of unactivated amides using 1,3,5-triazo-2,4,6-triphosphorine-2,2,4,4,6,6- hexachloride (TAPC)-based phosphorous/SO42- catalysis. The SO42- species in a reaction mixture enhances the reaction rate of the catalysis. In principle, no metal sources are required for the generation of the catalyst, and there is no requirement for the use of stoichiometric quantities of an acid or base. This catalyst system is operative under relatively acidic conditions. One major advantage of carrying out the reaction under acidic conditions is that both aldehydes and acetals are capable of undergoing carbon-carbon bond formation at the α-carbon of amide carbonyl groups through dehydration.