70783-32-3

Usage

Uses

Used in Pharmaceutical Industry:
4'-Phenoxy-2,2,2-trifluoroacetophenone is utilized as an intermediate or raw material for the synthesis of various organic compounds. Its role in the development of pharmaceuticals is significant, as it contributes to the creation of new drugs and medicines.
Used in Chemical Industry:
In the chemical industry, 4'-phenoxy-2,2,2-trifluoroacetophenone serves as a building block for the production of a range of organic compounds. Its versatility and stability make it a valuable component in chemical processes.
Used in Agrochemical Production:
4'-Phenoxy-2,2,2-trifluoroacetophenone is employed as a key component in the synthesis of agrochemicals. Its use in this industry helps in developing effective solutions for agricultural applications, such as pesticides and herbicides.
Used in Flavors and Fragrances Industry:
4'-PHENOXY-2,2,2-TRIFLUOROACETOPHENONE is also used as a building block in the production of flavors and fragrances. Its unique properties allow it to contribute to the development of various scent profiles and taste enhancements for consumer products.
It is important to handle 4'-phenoxy-2,2,2-trifluoroacetophenone with care due to its potential health and environmental hazards. Proper safety measures should be taken during its use and storage to minimize any risks associated with it.

InChI:InChI=1/C14H9F3O2/c15-14(16,17)13(18)10-6-8-12(9-7-10)19-11-4-2-1-3-5-11/h1-9H

Upstream product

• 101-84-8 diphenylether 
• 96254-05-6 2-(trifluoroacetyloxy)pyridine 
• 655-32-3 2,2,2-trifluoro-1-(4-fluorophenyl)ethanone 
• 108-95-2 phenol 
• 51067-38-0 4-phenoxyphenylboronic acid 
• 2215-77-2 4-Phenoxybenzoic acid 
• 81290-20-2 (trifluoromethyl)trimethylsilane 
• 101-55-3 4-Bromodiphenyl ether 
• 945761-06-8 N-methoxy-N-methyl-4-phenoxybenzamide 
• 76-05-1 trifluoroacetic acid 
• 16184-89-7 4'-bromo-2,2,2-trifluoroacetophenone 
• 139-02-6 sodium phenoxide 
• 21473-02-9 4-phenoxyphenylmagnesium bromide 
• 407-25-0 trifluoroacetic anhydride 

Downstream Products

• 96661-20-0 1,1,1-Trifluoro-2-(4-phenoxy-phenyl)-propan-2-ol 
• 192826-62-3 2,2,2-Trifluoro-1,1-bis-(4-phenoxy-phenyl)-ethanol 
• 70783-33-4 2,2,2-trifluoro-1-(4-phenoxyphenyl)ethan-1-ol 
• 6919-61-5 N-methoxy-N-methylbenzamide 
• 1233964-13-0 5-[1,1-bis(4-aminophenyl)-2,2,2-trifluoroethyl]-2-(4-sulfophenoxy)benzenesulfonic acid 
• 1233964-12-9 1,1-bis(4-aminophenyl)-1-(4-phenoxyphenyl)-2,2,2-trifluoroethane 
• 1414962-85-8 3,3,3-trifluoro-2-hydroxy-N-(4-methoxybenzyl)-2-(4-phenoxyphenyl)propanamide 
• 1476038-39-7 C₂₄H₂₀F₃NO₅ 
• 1476038-44-4 C₂₄H₂₀F₃NO₅ 
• 120039-67-0 Toluene-4-sulfonic acid 2,2,2-trifluoro-1-(4-phenoxy-phenyl)-ethyl ester 
• 122242-83-5 Toluene-4-sulfonic acid 2,2,2-trifluoro-1-methyl-1-(4-phenoxy-phenyl)-ethyl ester 
• 96661-23-3 1-(1-Bromo-2,2,2-trifluoro-1-methyl-ethyl)-4-phenoxy-benzene 
• 131543-90-3 C₂₆H₁₈BrF₃O₂ 
• 131543-83-4 1,1-bis(p-phenoxyphenyl)-2,2,2-trifluoroethyl chloride 

Relevant academic research and scientific papers

Trifluoromethylation of Benzoic Acids: An Access to Aryl Trifluoromethyl Ketones

The trifluoromethylation of benzoic acids with TMSCF3 was achieved through nucleophilic substitution with the use of anhydrides as an in situ activating reagent. Under the reaction conditions, a wide range of carboxylic acids including the bioactive ones worked well, thus providing a facile and efficient method for preparing aryl trifluoromethyl ketones from the readily available starting materials.

Access to Aryl and Heteroaryl Trifluoromethyl Ketones from Aryl Bromides and Fluorosulfates with Stoichiometric CO

We report a sequential one-pot preparation of aromatic trifluoromethyl ketones starting from readily accessible aryl bromides and fluorosulfates, the latter easily prepared from the corresponding phenols. The methodology utilizes low pressure carbon monoxide generated ex situ from COgen to generate Weinreb amides as reactive intermediates that undergo monotrifluoromethylation affording the corresponding aromatic trifluoromethyl ketones (TFMKs) in good yields. The stoichiometric use of CO enables the possibility for accessing 13C-isotopically labeled TFMK by switching to the use of 13COgen.

N-phenyl-N-p-toluenesulfonyl trifluoroacetamide (NTFTS) and application

The invention belongs to the technical field of medical chemical engineering intermediates and related chemistry, and relates to N-phenyl-N-p-toluenesulfonyl trifluoroacetamide (NTFTS) and application. The N-phenyl-N-p-toluenesulfonyl trifluoroacetamide is taken as a trifluoroacetylation reagent, reacts with an arylboronic acid derivative in an anhydrous organic solvent under the action of a metalcatalyst, a ligand and an alkali, and is efficiently and highly selectively converted into a trifluoroacetophenone compound. According to a synthesis method of the trifluoroacetophenone compound, involved in the invention, reaction steps are few; the NTFTS which is stable in use, easy to store, cheap and easy to get is taken as a trifluoroacetyl source; environmental friendliness is realized; reaction conditions are mild; operation is easy; a high-yield and high-selectivity target product is obtained and has relatively good industrial production value and practical application value. The trifluoroacetophenone compound synthesized by utilizing the method can be further subjected to a functionalization reaction, and can be widely applied to the synthetic fields of medicine, pesticide, bioactive molecules, functional material molecules and the like.

Synthesis and characterization of sulfonated polyimides bearing sulfonated aromatic pendant group for DMFC applications

A novel side-chain-type sulfonated aromatic diamine, 5-[1,1-bis(4-aminophenyl)-2,2,2- trifluoroethyl]-2-(4-sulfophenoxy)benzenesulfonic acid (BABSA) was synthesized and characterized. Two series of sulfonated polymides (SPI-N and SPI-B) were prepared from 1,4,5,8-naphthalene tetracarboxylic dianhydride (NTDA) or 4,4'-binaphthyl-1,1',8,8'-tetracarboxylic dianhydride (BNTDA), sulfonated diamine BABSA and various non-sulfonated aromatic diamines. The resulting sulfonated polyimide (SPI) membranes exhibited good dimensional stability with isotropic swelling of 7-22% and high thermal stability with desulfonation temperature of 283-330 °C. These membranes also displayed excellent oxidation stability and good water stability. The SPI membranes exhibited better permselectivity than Nafion 115 membrane due to their much lower methanol permeability. The ratios of proton conductivity to methanol permeability (F{cyrillic}) for the SPI membranes were almost two to three times of that for Nafion 115. The SPI-N membranes exhibited excellent conducting performance with the proton conductivity higher than Nafion 115 as the temperature over 40 °C, which attributed to their good hydrophobic/hydrophilic microphase separation structure.

Palladium-catalyzed formation of diaryl ethers from aryl bromides. Electron poor phosphines enhance reaction yields

Aryl bromides were converted to diaryl ethers with sodium aryl oxides in the presence of catalytic amounts of Pd(DBA)2 and DPPF. Isolated yields of over 90% were achieved in reactions with electron deficient aryl bromides and electron rich sodium aryl oxides. Electron poor DPPF derivatives led to increased reaction yields.

A simple method for the preparation of aryl trifluoromethyl ketones

4-Dimethylamino-1-trifluoroacetylpyridinium trifluoroacetate (2) is an effective, easy to handle and stable trifluoroacetylation agent. Aryl trifluormethyl ketones 4 are obtained in good yields by reaction of 2 with aromatic compounds 3 in the presence of aluminum chloride.

A Convenient Trifluoroacetylation of Arenes with 2-(Trifluoroacetoxy)pyridine

2-(Trifluoroacetoxy)pyridine (TFAP) is useful for trifluoroacetylating arenes under Friedel-Crafts conditions.Benzene, alkylbenzenes, naphthalene, and dibenzofuran have reacted with TFAP in the presence of aluminum chloride in dichloromethane to give the corresponding trifluoromethyl aryl ketones in good isolated yields.

Derivatives of arylalkanoic acids, compositions and use

There are now described some novel alpha-[1-aryl-2,2,2-trifluoroethoxy (or-ethylthio)]alkanoic acids that are useful for reducing triglycerides and cholesterol levels in the blood of animals. The percentage reduction in test rats has been observed to be from 20 to 65 for triglycerides and from 15 to 50 for cholesterol. A representative compound of the invention is alpha-(2,2,2-trifluoro-1-phenyl-1-ethoxy)butyric acid. Most of the compounds have an LD50 greater than 800 mg/kg, intraperitoneally, in male mice. A method of use, compositions, and a process for synthesis are also described.