70783-32-3

Basic information

• Product Name: 4'-PHENOXY-2,2,2-TRIFLUOROACETOPHENONE
• Synonyms: 2,2,2-TRIFLUORO1-(4-PHENOXYPHENYL)ETHANONE;4'-PHENOXY-2,2,2-TRIFLUOROACETOPHENONE
• CAS NO: 70783-32-3
• Molecular Formula: C₁₄H₉F₃O₂
• Molecular Weight: 266.22
• Mol File: 70783-32-3.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 319.2 °C at 760 mmHg
• Flash Point: 142.1 °C
• Appearance: /
• Density: 1.28 g/cm³
• Vapor Pressure: 0.000344mmHg at 25°C
• Refractive Index: 1.519
• CAS DataBase Reference: 4'-PHENOXY-2,2,2-TRIFLUOROACETOPHENONE(CAS DataBase Reference)
• NIST Chemistry Reference: 4'-PHENOXY-2,2,2-TRIFLUOROACETOPHENONE(70783-32-3)
• EPA Substance Registry System: 4'-PHENOXY-2,2,2-TRIFLUOROACETOPHENONE(70783-32-3)

Safety Data

• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• Hazardous Substances Data: 70783-32-3(Hazardous Substances Data)

Usage

General Description

4'-Phenoxy-2,2,2-trifluoroacetophenone is a chemical compound with the molecular formula C14H9F3O2. It is a white solid with a melting point of 52-55°C and a boiling point of 200-202°C. 4'-PHENOXY-2,2,2-TRIFLUOROACETOPHENONE is widely used in the pharmaceutical and chemical industries as an intermediate or raw material for the synthesis of various organic compounds. It is also used as a building block in the production of agrochemicals, flavors, and fragrances. Additionally, 4'-phenoxy-2,2,2-trifluoroacetophenone is known for its high chemical stability and can be easily handled and stored. However, it should be handled with care due to its potential health and environmental hazards.

InChI:InChI=1/C14H9F3O2/c15-14(16,17)13(18)10-6-8-12(9-7-10)19-11-4-2-1-3-5-11/h1-9H

Upstream product

• 101-84-8 diphenylether 
• 2215-77-2 4-Phenoxybenzoic acid 
• 81290-20-2 (trifluoromethyl)trimethylsilane 
• 101-55-3 4-Bromodiphenyl ether 
• 945761-06-8 N-methoxy-N-methyl-4-phenoxybenzamide 
• 51067-38-0 4-phenoxyphenylboronic acid 
• 76-05-1 trifluoroacetic acid 
• 655-32-3 2,2,2-trifluoro-1-(4-fluorophenyl)ethanone 
• 108-95-2 phenol 
• 16184-89-7 4'-bromo-2,2,2-trifluoroacetophenone 
• 139-02-6 sodium phenoxide 
• 21473-02-9 4-phenoxyphenylmagnesium bromide 
• 407-25-0 trifluoroacetic anhydride 
• 96254-05-6 2-(trifluoroacetyloxy)pyridine 

Downstream Products

• 131543-83-4 1,1-bis(p-phenoxyphenyl)-2,2,2-trifluoroethyl chloride 
• 131543-90-3 C₂₆H₁₈BrF₃O₂ 
• 1233964-13-0 5-[1,1-bis(4-aminophenyl)-2,2,2-trifluoroethyl]-2-(4-sulfophenoxy)benzenesulfonic acid 
• 1233964-12-9 1,1-bis(4-aminophenyl)-1-(4-phenoxyphenyl)-2,2,2-trifluoroethane 
• 1414962-85-8 3,3,3-trifluoro-2-hydroxy-N-(4-methoxybenzyl)-2-(4-phenoxyphenyl)propanamide 
• 1476038-39-7 C₂₄H₂₀F₃NO₅ 
• 1476038-44-4 C₂₄H₂₀F₃NO₅ 
• 120039-67-0 Toluene-4-sulfonic acid 2,2,2-trifluoro-1-(4-phenoxy-phenyl)-ethyl ester 
• 122242-83-5 Toluene-4-sulfonic acid 2,2,2-trifluoro-1-methyl-1-(4-phenoxy-phenyl)-ethyl ester 
• 96661-23-3 1-(1-Bromo-2,2,2-trifluoro-1-methyl-ethyl)-4-phenoxy-benzene 
• 6919-61-5 N-methoxy-N-methylbenzamide 
• 70783-33-4 2,2,2-trifluoro-1-(4-phenoxyphenyl)ethan-1-ol 
• 192826-62-3 2,2,2-Trifluoro-1,1-bis-(4-phenoxy-phenyl)-ethanol 
• 96661-20-0 1,1,1-Trifluoro-2-(4-phenoxy-phenyl)-propan-2-ol 

Relevant articles and documents

Trifluoromethylation of Benzoic Acids: An Access to Aryl Trifluoromethyl Ketones

The trifluoromethylation of benzoic acids with TMSCF3 was achieved through nucleophilic substitution with the use of anhydrides as an in situ activating reagent. Under the reaction conditions, a wide range of carboxylic acids including the bioactive ones worked well, thus providing a facile and efficient method for preparing aryl trifluoromethyl ketones from the readily available starting materials.

N-phenyl-N-p-toluenesulfonyl trifluoroacetamide (NTFTS) and application

The invention belongs to the technical field of medical chemical engineering intermediates and related chemistry, and relates to N-phenyl-N-p-toluenesulfonyl trifluoroacetamide (NTFTS) and application. The N-phenyl-N-p-toluenesulfonyl trifluoroacetamide is taken as a trifluoroacetylation reagent, reacts with an arylboronic acid derivative in an anhydrous organic solvent under the action of a metalcatalyst, a ligand and an alkali, and is efficiently and highly selectively converted into a trifluoroacetophenone compound. According to a synthesis method of the trifluoroacetophenone compound, involved in the invention, reaction steps are few; the NTFTS which is stable in use, easy to store, cheap and easy to get is taken as a trifluoroacetyl source; environmental friendliness is realized; reaction conditions are mild; operation is easy; a high-yield and high-selectivity target product is obtained and has relatively good industrial production value and practical application value. The trifluoroacetophenone compound synthesized by utilizing the method can be further subjected to a functionalization reaction, and can be widely applied to the synthetic fields of medicine, pesticide, bioactive molecules, functional material molecules and the like.

Palladium-catalyzed formation of diaryl ethers from aryl bromides. Electron poor phosphines enhance reaction yields

Aryl bromides were converted to diaryl ethers with sodium aryl oxides in the presence of catalytic amounts of Pd(DBA)2 and DPPF. Isolated yields of over 90% were achieved in reactions with electron deficient aryl bromides and electron rich sodium aryl oxides. Electron poor DPPF derivatives led to increased reaction yields.