17049-41-1

Basic information

• Product Name: 1-(TRIMETHYLSILYL)-4-PHENOXYBENZENE
• Synonyms: 1-(TRIMETHYLSILYL)-4-PHENOXYBENZENE
• CAS NO: 17049-41-1
• Molecular Formula: C₁₅H₁₈OSi
• Molecular Weight: 242.39
• Mol File: 17049-41-1.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 147-148 °C(Press: 6 Torr)
• Appearance: /
• Density: 1.0110 g/cm3
• CAS DataBase Reference: 1-(TRIMETHYLSILYL)-4-PHENOXYBENZENE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(TRIMETHYLSILYL)-4-PHENOXYBENZENE(17049-41-1)
• EPA Substance Registry System: 1-(TRIMETHYLSILYL)-4-PHENOXYBENZENE(17049-41-1)

Safety Data

• Hazardous Substances Data: 17049-41-1(Hazardous Substances Data)

Usage

General Description

1-(trimethylsilyl)-4-phenoxybenzene is a chemical compound that consists of a benzene ring with a phenoxy group and a trimethylsilyl group attached. It is commonly used as a reagent in organic synthesis, particularly in the preparation of various functionalized organic compounds. The trimethylsilyl group is a commonly used protecting group in organic chemistry, while the phenoxy group is known for its ability to stabilize radicals and participate in various types of chemical reactions. 1-(TRIMETHYLSILYL)-4-PHENOXYBENZENE is often used in the synthesis of pharmaceuticals, agrochemicals, and materials science applications due to its versatility and stability.

Upstream product

• 75-77-4 chloro-trimethyl-silane 
• 101-55-3 4-Bromodiphenyl ether 
• 6999-03-7 1-bromo-4-(trimethylsilyl)benzene 
• 108-95-2 phenol 
• 10557-71-8 4-chlorophenyltrimethylsilane 
• 21473-02-9 4-phenoxyphenylmagnesium bromide 

Downstream Products

• 133408-73-8 (E)-N-methyl-2-[2-(4-trimethylsilylphenoxy)phenyl]-2-methoxyiminoacetamide 
• 18870-59-2 10,10-diphenyl-2-trimethylsilanyl-10H-phenoxasiline 

Relevant articles and documents

Potassium Hydride as Nucleophile: A Practical Method for Cleavage and Functional Modification of Cr(CO)3-Ar-SiMe3 Bonds

Potassium hydride reacts with Cr(CO)3-aryltrimethylsilanes at room temperature to generate stabilized aryl anions which can further react with electrophiles.

CuI/oxalamide catalyzed couplings of (hetero)aryl chlorides and phenols for diaryl ether formation

Couplings between (hetero)aryl chlorides and phenols can be effectively promoted by CuI in combination with an N-aryl-N′-alkyl-substituted oxalamide ligand to proceed smoothly at 120 °C. For this process, N-aryl-N′-alkyl-substituted oxalamides are more effective ligands than bis(N-aryl)-substituted oxalamides. A wide range of electron-rich and electron-poor aryl and heteroaryl chlorides gave the corresponding coupling products in good yields. Satisfactory conversions were achieved with electron-rich phenols as well as a limited range of electron-poor phenols. Catalyst and ligand loadings as low as 1.5 mol % are sufficient for the scaled-up variants of some of these reactions. Aryl and alkyl: N-Aryl-N′-alkyl-substituted oxalamide ligands promote the CuI catalyzed coupling of (hetero)aryl chlorides and phenols at 120 °C more effectively than bis(N-aryl)-substituted oxalamides. A wide range of electron-rich and electron-poor aryl and heteroaryl chlorides were converted into the corresponding coupling products in good yields.