214759-42-9

Basic information

• Product Name: 1-[4-(aminomethyl)phenyl]-1-ethanol
• Synonyms: 1-[4-(aminomethyl)phenyl]-1-ethanol
• CAS NO: 214759-42-9
• Molecular Weight: 151.208
• Mol File: 214759-42-9.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: 1-[4-(aminomethyl)phenyl]-1-ethanol(CAS DataBase Reference)
• NIST Chemistry Reference: 1-[4-(aminomethyl)phenyl]-1-ethanol(214759-42-9)
• EPA Substance Registry System: 1-[4-(aminomethyl)phenyl]-1-ethanol(214759-42-9)

Safety Data

• Hazardous Substances Data: 214759-42-9(Hazardous Substances Data)

Usage

Functional groups

Amine and alcohol

Chemical classification

Phenethylamine derivative

Applications

a. Synthesis of pharmaceuticals
b. Synthesis of organic chemicals
c. Reagent in organic and medicinal chemistry research

Biological activities

Potential for various biological activities (currently being studied)

Pharmacological properties

Being studied for potential properties

Effects

May have both therapeutic and toxicological effects

Safety precautions

Should be handled and used with appropriate care and caution

Upstream product

• 1443-80-7 4-cyanophenyl methyl ketone 
• 7441-43-2 4-ethylbenzylamine 

Downstream Products

• 1143464-08-7 1-[4-(aminomethyl)phenyl]ethyl benzoate 
• 1143464-10-1 [4-(benzoylaminomethyl)phenyl]ethyl benzoate 
• 1039454-77-7 N-(4-acetylbenzyl)benzamide 
• 1241606-80-3 C₂₁H₂₅FN₂O₂ 
• 1241461-78-8 C₂₅H₂₇N₃O₃ 
• 1241575-46-1 1-[1-(3,4-diethoxy-phenyl)-ethyl]-3-[4-(1-hydroxy-ethyl)-benzyl]-urea 

Relevant articles and documents

Ruthenium complex based on [N,N,O] tridentate -2-ferrocenyl-2-thiazoline ligand for catalytic transfer hydrogenation

A method for the synthesis of a new phosphine-free [N,N,O]-tridentate Schiff base ligand L1 using the 2-Ferrocenyl-2-thiazoline as scaffold was developed. The 1,2-disubstituted ferrocene-based ligand was assembled using as key strategy the directed ortho-metalation (DoM) in 2-ferrocenyl-2-thiazoline. L1 was successfully obtained in 83% of overall yield after two-step synthesis. The coordination ability of L1 towards Ru(II) was evidenced and the resulting complex was characterized by IR, UV-vis and EPR. Its catalytic performance was tested in transfer hydrogenation of a variety of substrates giving moderate to excellent conversions.

Hydrosilane Reduction of Nitriles to Primary Amines by Cobalt-Isocyanide Catalysts

Reduction of nitriles to silylated primary amines was achieved by combination of 1,1,3,3-tetramethyldisiloxane (TMDS) as the hydrosilane and a catalytic amount of Co(OPIV)2 (PIV = COtBu) associated with isocyanide ligands. The resulting silylated amines were subjected to acid hydrolysis or treatment with acid chlorides to give the corresponding primary amines or imides in good yields. One-pot synthesis of primary amides to primary amines with hydrosilanes was also achieved by iron-cobalt dual catalyst systems.

DUAL SITE CATALYST FOR MILD, SELECTIVE NITRILE REDUCTION

A ruthenium bis(pyrazolyl)borate scaffold that enables cooperative reduction reactivity in which boron and ruthenium centers work in concert to effect selective nitrile reduction is provided. The pre-catalyst compound [κ3-(1-pz)2HB(N═CHCH3)]Ru(cymene)? TfO? (pz=pyrazolyl) was synthesized using readily-available materials through a straightforward route, thus making it an appealing catalyst for a number of reactions.