214836-81-4

Upstream product

• 139630-91-4 (E)-2-methyl-3-(2-methyloxazol-4-yl)acrylaldehyde 
• 182193-69-7 (S)-1-(p-methoxybenzyloxy)-2-methylpentan-3-one 

Downstream Products

• 214836-83-6 Acetic acid (1R,2R,3S,4S)-3-hydroxy-5-(4-methoxy-benzyloxy)-2,4-dimethyl-1-[(E)-1-methyl-2-(2-methyl-oxazol-4-yl)-vinyl]-pentyl ester 
• 214836-84-7 Isobutyric acid (1R,2R,3S,4S)-3-hydroxy-5-(4-methoxy-benzyloxy)-2,4-dimethyl-1-[(E)-1-methyl-2-(2-methyl-oxazol-4-yl)-vinyl]-pentyl ester 

Relevant academic research and scientific papers

Towards the total synthesis of phorboxazoles A and B: Stereocontrolled synthesis of a C20-C32 subunit

The C20-C32 phorboxazole subunit 4, containing 5 stereocentres, was prepared in 8 steps (34%) from ethyl ketone (S)-7. Key steps included a boron-mediated anti aldol reaction and an intramolecular hetero-michael reaction. Installatio

Toward the total synthesis of phorboxazole A: Synthesis of an advanced C4-C32 subunit using the Jacobsen hetero Diels-Alder reaction

The tetrahydropyranone 3, representing a pentacyclic C4-C32 segment of the phorboxazoles, was obtained by a complex hetero Diels-Alder (HDA) coupling performed between the 2-siloxydiene 23 and the oxazole aldehyde 4, mediated by the