214892-30-5Relevant academic research and scientific papers
Synthesis of Novel Nucleoside Analogues Built on a Bicyclo[4.1.0]heptane Scaffold
Dom?nguez-Pérez, Beatriz,Ferrer, éric,Figueredo, Marta,Maréchal, Jean-Didier,Balzarini, Jan,Alibés, Ramon,Busqué, Félix
, p. 9495 - 9505 (2015/10/12)
A new class of carbocyclic nucleoside analogues built on a bicyclo[4.1.0]heptane scaffold, a perspective novel pseudosugar pattern, have been conceived as anti-HSV agents on the basis of initial protein-ligand docking studies. The asymmetric synthesis of a series of these compounds incorporating different nucleobases has been efficiently completed starting from 1,4-cyclohexanedione.
Enantiodivergent synthesis of cyclohexenyl nucleosides
Ferrer, Eric,Alibes, Ramon,Busque, Felix,Figueredo, Marta,Font, Josep,De March, Pedro
supporting information; experimental part, p. 2425 - 2432 (2009/09/06)
An enantiodivergent synthesis of several cyclohexenyl nucleosides has been efficiently completed starting from the enantiopure hydrobenzoin-derived monoketal of cyclohex-2-en-1,4-dione, (+)-5. Stereodiversity was accomplished on the base coupling step. Th
From p-benzoquinone to cyclohexane chirons: First asymmetric synthesis of (+)-rengyolone and (+)- and (-)-menisdaurilide
Busque, Felix,Canto, Mariona,De March, Pedro,Figueredo, Marta,Font, Josep,Rodriguez, Sonia
, p. 2021 - 2032 (2007/10/03)
Starting from a common, easily available, enantiopure monoketal of p-benzoquinone, the synthesis of a large number of cyclohexane chirons has been achieved. The first synthesis of (+)-rengyolone and (+)- and (-)-menisdaurilide has been performed from one of these new building blocks. The wide variety of functional groups of this series of chirons makes them useful for subsequent synthetic processes.
Synthesis of agarofuran antifeedants. Part 6: Enantioselective synthesis of a key decalinic intermediate
Boyer, Francois-Didier,Prange, Thierry,Ducrot, Paul-Henri
, p. 1153 - 1159 (2007/10/03)
The asymmetric synthesis of a template decalin precursor in the synthesis of polyhydroxylated agarofuran sesquiterpenes is described via a Lewis acid catalysed addition of furan to an activated cyclohexenone directed by an adjacent chiral ketal moiety.
From p-benzoquinone to useful chiral cyclohexane building blocks
Busque, Felix,De March, Pedro,Figueredo, Marta,Font, Josep,Rodriguez, Sonia
, p. 3077 - 3080 (2007/10/03)
A straightforward and efficient access to 12 new cyclohexane chirons from an easily available enantiopure monoketal of p-benzoquinone is described. These chirons possess a variety of functional groups which render them useful for further synthetic elabora
