2149-49-7

Upstream product

• 127-17-3 2-oxo-propionic acid 
• 108-95-2 phenol 
• 618-32-6 Benzoyl bromide 
• 124-38-9 carbon dioxide 
• 74-88-4 methyl iodide 

Downstream Products

• 1224699-71-1 (S)-phenyl 2-hydroxy-2-methyl-4-oxopentanoate 
• 36065-27-7 N-α-phenylethylacetamide 
• 122-78-1 phenylacetaldehyde 
• 7292-85-5 (2R)-Phenyllactat 
• 86577-51-7 phenyl threo-2,3-dimethyl-2-hydroxy-4-pentenoate 
• 86577-51-7 phenyl erythro-2,3-dimethyl-2-hydroxy-4-pentenoate 
• 100701-86-8 phenyl threo-2,3-dimethyl-2-hydroxy-5-(trimethylsilyl)-4-pentynoate 
• 100701-86-8 phenyl erythro-2,3-dimethyl-2-hydroxy-5-(trimethylsilyl)-4-pentynoate 

Relevant academic research and scientific papers

On the mechanism of chorismate mutases: Revisiting structural requirements for catalysis

The behavior of nor-chorismic acid 7 has now been tested against three different chorismate mutases. Notably, 7 is not a substrate for Bacillus subtilis mutase, but is a weak competitive inhibitor (K(I) = 0.5 mM).

Electrocatalytic carboxylation of benzoyl bromide with CO2 in ionic liquid 1-butyl-3-methyllimidazoliumtetrafluoborate to methyl phenyl glyoxylate

A new electrochemical procedure for the electrocatalytic carboxylation of benzoyl bromide with CO2 in ionic liquid, 1-butyl-3- methyllimidazolium tetrafluoborate (BMIMBF4), to methyl phenyl glyoxylate was investigated. The experiments were carried out in three electrodes undivided cell under mild conditions and the use of volatile and toxic solvents and catalysts, as well as any other additional supporting electrolytes, was avoided. The electrochemical reduction behavior of benzoyl bromide in BMIMBF4 had been studied by cyclic voltammetry with a reduction peak at -1.6 V (vs. Ag). Methyl phenyl glyoxylate was obtained by typical electrolytic procedure.

Metal-Free Synthesis of Polysubstituted Imidazolinone Through Cyclization of Amidines with 2-Substituted Acrylates

Polysubstituted imidazolinones were synthesized in a facile metal-free cascade nucleophilic cyclization of easily available amidines and 2-substituted acrylates. This protocol is distinguished by simple, mild, and catalyst-free reaction conditions with a broad substrate scope, affording the desired products in moderate to good yields and providing an efficient strategy for synthesis of polysubstituted imidazolinone.

Synthesis of Dihydro-2-oxopyrrole (DPO) Building Blocks Catalyzed by Potassium Carbonate

A dimerization and cyclization cascade reaction of 2-sulfonaminoacrylates catalyzed by K2CO3 provides dihydro-2-oxopyrrole (DPO) derivatives. This straightforward and atom-economic transformation features a simple experimental operation with easily available starting materials, a broad substrate scope as well as good functional group tolerance. The desired DPO building blocks are obtained in moderate to good yields.

H8-BINOL chiral imidodiphosphoric acids catalyzed enantioselective synthesis of dihydroindolo-/-pyrrolo[1,2- a ]quinoxalines

The first enantioselective synthesis of 5,6-dihydroindolo[1,2-a]quinoxalines is achieved by using a newly developed H8-BINOL-type imidodiphosphoric acid catalyst with low catalyst loading through efficient Pictet-Spengler-type reactions of indolyl anilines with ketones. This methodology also generates phenyl-4,5-dihydropyrrolo[1,2-a]quinoxalines with high yields and excellent enantioselectivities. Moreover, this method was utilized to synthesize an HIV-1 inhibitor with high yield and good enantioselectivity through a one-step procedure.

Process for the preparation of monohydrated sodium phenylpyruvate

A process for the preparation of monohydrated sodium phenylpyruvate comprises reacting benzaldehyde with the stoichiometric quantity of hydantoin in the aqueous medium in the presence of a catalytic quantity of a primary or secondary amine at high tempera

Diastereodivergent Control in the Reactions of Allylic and Allenic Organometallic Reagents with Pyruvates

The reaction of crotyl-9-BBN (4a) with pyruvates (3) produced the threo (anti) isomer 5 either predominantly or exclusively.On the other hand, the reaction of allenic organometallic reagents 18 (M = B or Ti) gave the erythro (syn) isomer 20 preferentially