214903-47-6

Upstream product

• 453-71-4 3-nitro-4-fluorobenzoic acid 
• 100-52-7 benzaldehyde 
• 100-46-9 benzylamine 
• 68502-46-5 4-benzylamine-3-nitro-benzoic acid methyl ester 
• 68502-22-7 3-amino-4-benzylamine-benzoic acid methyl ester 
• 66315-38-6 3-Amino-4-phenylmethylaminobenzoic acid 

Relevant academic research and scientific papers

'One-pot' nitro reduction-cyclisation solid phase route to benzimidazoles

An improved solid phase synthesis of benzimidazoles is described. A polymer-bound o-nitroaniline was reacted with aldehydes in DMF in the presence of SnCl2·2H2O at 60°C for three hours to give benzimidazoles in excellent purity and good yield after TFA cleavage. A library of 25 benzimidazoles was prepared using this 'one-pot' procedure. (C) 2000 Elsevier Science Ltd.

Synthesis of some new benzimidazolecarboxamides and evaluation of their antimicrobial activity

A series of 1,2-disubstituted benzimidazole-5(6)-carboxamides was prepared and evaluated in vitro for antimicrobial activity against Staphyloccus aureus, Escherichia coli and Candida albicans. The precursor benzimidazolecarboxylic acids 4a-c and 9a-c were