21493-89-0

Upstream product

• 356552-15-3 (4-methoxyphenyl)(5-methylfuran-2-yl)methanol 
• 620-02-0 5-Methylfurfural 
• 104-92-7 1-bromo-4-methoxy-benzene 
• 534-22-5 2-methylfuran 
• 4231-69-0 1-(4-methoxybenzoyl)-1H-1,2,3-benzotriazole 

Relevant academic research and scientific papers

Cobalt-Catalyzed Oxygenation/Dearomatization of Furans

The dearomatization of aromatic compounds using cobalt(II) acetylacetonate with triplet oxygen and triethylsilane converts furans, benzofurans, pyrroles, and thiophenes to a variety of products, including lactones, silyl peroxides, and ketones.

C-acylation of 2-methylfuran and thiophene using N-acylbenzotriazoles

Reactions of 2-methylfuran and thiophene with readily available N-acylbenzotriazoles (RCOBt, where R = 4-tolyl, 4-methoxyphenyl, benzyl, 4-nitrophenyl, 4-diethylaminophenyl, 2-pyridyl and 1-naphthyl) in the presence of TiCl4 or ZnBr2 produced 2-methyl-4-acylfurans 2a-e and 2-acylthiophenes 3a-f in average yields of 54 % and 75 %, respectively. Literature yields for the preparation of the same compounds are significantly lower.