21504-08-5Relevant academic research and scientific papers
Weinreb amide based building blocks for convenient access to 1,1-diarylethenes and isocombretastatin analogues
Balasubramaniam, Sivaraman,Kommidi, Harikrishna,Aidhen, Indrapal Singh
supporting information; experimental part, p. 2683 - 2686 (2011/06/19)
A successful strategy based on the synthetic equivalent containing Weinreb amide functionality for the convenient access to 1,1-diarylethenes in general and for the isocombretastatin analogues in particular has been developed from the commercially available glyoxalic acid. The convenience with which the structural variations can be made in assembling the aryl residues shows generality associated with the developed strategy. The intermediates also provide access to 1,2,2-triarylethanones, represented by the synthesis of advanced intermediate of tamoxifen.
Synthetic equivalents based on Weinreb amide functionality for convenient access to monoprotected α-diketones
Balasubramaniam, Sivaraman,Aidhen, Indrapal Singh
, p. 959 - 963 (2008/02/02)
A convenient new strategy for the synthesis of monoprotected α-diketones has been achieved. The strategy is based on the use of hitherto unreported N-methoxy-N-methyl-1,3-dithiolane-2-carboxamide and N-methoxy-N-methyl-1,3-dithiane-2-carboxamide as synthe
Generation of α-Oxo Dithioesters by Dithiolanium Ylide Cycloreversion. Synthesis of 2-Acyl-3,6-dihydro-2H-thiopyrans
Vedejs, E.,Arnost, M. J.,Dolphin, J. M.,Eustache, J.
, p. 2601 - 2604 (2007/10/02)
Methylation of 2-acyl-1,3-dithiolanes with CH3OSO2F affords sulfonium salts which undergo cycloreversion to α-oxo dithioesters RCOCS2CH3 (R=CH3,C6H5).In the presence of dienes (2,3-dimethyl-, 1-methyl-, or 1,3-dimethylbutadiene), good yields of 2-acyl-2-(
