215317-22-9

Usage

Uses

Used in Pharmaceutical Industry:
(2R)-4-hydroxy-5-[(1R)-1-(3-nitrophenyl)propyl]-2-phenethyl-2-propyl-3H-pyran-6-one is used as a potential pharmaceutical compound for its unique molecular structure and stereochemistry. The presence of hydroxyl and nitro groups, along with the phenethyl and propyl groups, may contribute to its biological activity and interactions with biological targets, making it a candidate for drug development.
Used in Materials Science:
In the field of materials science, (2R)-4-hydroxy-5-[(1R)-1-(3-nitrophenyl)propyl]-2-phenethyl-2-propyl-3H-pyran-6-one may be utilized for its structural properties and potential to form novel materials with specific characteristics. (2R)-4-hydroxy-5-[(1R)-1-(3-nitrophenyl)propyl]-2-phenethyl-2-propyl-3H-pyran-6-one's chiral centers and side chains could influence its self-assembly, aggregation, or interaction with other molecules, leading to applications in areas such as nanotechnology, polymer science, or advanced materials development.

Upstream product

• 215316-59-9 (R)-3-hydroxy-3-(2-phenylethyl)-hexanoic acid 
• 215317-19-4 (R)-5-(Biphenyl-4-yloxymethoxy)-2-[(S)-1-(3-nitro-phenyl)-propyl]-3-oxo-5-phenethyl-octanoic acid methyl ester 
• 215317-17-2 (R)-5-(Biphenyl-4-yloxymethoxy)-3-hydroxy-2-[(S)-1-(3-nitro-phenyl)-propyl]-5-phenethyl-octanoic acid methyl ester 
• 215317-08-1 (R)-(4-phenylphenoxy)methyl-3-(2-phenylethyl)-3-[(4-phenylphenoxy)methoxy]hexanoate 
• 215317-14-9 (R)-3-(2-phenylethyl)-3-[(4-phenylphenoxy)methoxy]hexanal 
• 215317-11-6 (R)-3-(2-phenylethyl)-3-[(4-phenylphenoxy)methoxy]hexanol 
• 215317-20-7 (R)-5-Hydroxy-2-[(S)-1-(3-nitro-phenyl)-propyl]-3-oxo-5-phenethyl-octanoic acid methyl ester 

Downstream Products

• 1141510-05-5 (6R)-4-hydroxy-3-[(R)-1-(3-hydroxyaminophenyl)-1-propyl]-6-phenethyl-6-propyl-5,6-dihydro-2H-pyran-2-one 
• 174484-41-4 tipranavir 
• 174485-90-6 (R)-3-[(R)-1-(3-Amino-phenyl)-propyl]-4-hydroxy-6-phenethyl-6-propyl-5,6-dihydro-pyran-2-one 

Relevant academic research and scientific papers

2,5-Dimethyl-3,4-bis[(2R,5R)-2,5-dimethylphospholano]thiophene: First member of the hetero-DuPHOS family

The 2,5-dimethyl-3,4-bis[(2R,5R)-2,5-dimethylphospholano]thiophene (UlluPHOS), a new thiophene-based analogue of (R,R)-1,2-bis(phospholano)benzene (Me-DuPHOS), was synthesized, geometrically and electronically characterized, and employed as ligand of Rh and Ru in some standard hydrogenation reactions of prostereogenic functionalized carbon-carbon and carbon-oxygen double bonds. The synthesis of UlluPHOS is much easier than that provided for Me-DuPHOS. UlluPHOS and Me-DuPHOS display very similar geometries, while the electronic availability of the former is higher than that exhibited by the latter. The Rh and Ru complexes of UlluPHOS produced excellent enantiomeric excesses (98.9-99.5%) in the hydrogenation of N-acetyl-α-enamino acids and reaction rates higher than those found when employing the analogous complexes of Me-DuPHOS.

A convergent, scalable synthesis of HIV protease inhibitor PNU-140690

PNU-140690, an inhibitor of the HIV protease enzyme undergoing clinical evaluation as a chemotherapeutic agent for treatment of AIDS, was synthesized by a convergent approach amenable to large-scale preparation in a pilot plant environment. The key step is the aldol addition of nitroaromatic ester (+)-8 to aldehyde 19e. The two stereocenters present in the target molecule were each set independently by resolution of enantiomers. Intermediates along the synthetic routes were chosen to maximize opportunities for isolation and purification by crystallization.