(2R)-4-hydroxy-5-[(1R)-1-(3-nitrophenyl)propyl]-2-phenethyl-2-propyl-3H-pyran-6-one

Base Information

Chemical Name:(2R)-4-hydroxy-5-[(1R)-1-(3-nitrophenyl)propyl]-2-phenethyl-2-propyl-3H-pyran-6-one
CAS No.:215317-22-9
Molecular Formula:C₂₅H₂₉NO₅
Molecular Weight:423.509
Hs Code.:

Synonyms:(6R)-4-hydroxy-3-[1-(3-nitrophenyl)-1-propyl]-6-phenethyl-6-propyl-5,6-dihydro-2H-pyran-2-one

Suppliers and Price of (2R)-4-hydroxy-5-[(1R)-1-(3-nitrophenyl)propyl]-2-phenethyl-2-propyl-3H-pyran-6-one

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2R)-4-hydroxy-5-[(1R)-1-(3-nitrophenyl)propyl]-2-phenethyl-2-propyl-3H-pyran-6-one

Chemical Property:

Vapor Pressure:1.25E-14mmHg at 25°C

Purity/Quality:: 98% HPLC ^*data from raw suppliers

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Technology Process of (2R)-4-hydroxy-5-[(1R)-1-(3-nitrophenyl)propyl]-2-phenethyl-2-propyl-3H-pyran-6-one

There total 8 articles about (2R)-4-hydroxy-5-[(1R)-1-(3-nitrophenyl)propyl]-2-phenethyl-2-propyl-3H-pyran-6-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.1%

: 215317-20-7
(R)-5-Hydroxy-2-[(S)-1-(3-nitro-phenyl)-propyl]-3-oxo-5-phenethyl-octanoic acid methyl ester

: 215317-22-9
(6R)-4-hydroxy-3-[1-(3-nitrophenyl)-1-propyl]-6-phenethyl-6-propyl-5,6-dihydro-2H-pyran-2-one

Guidance literature:: With sodium hydroxide; In methanol; at 0 - 5 ℃; for 67h;
DOI:10.1021/jo9809229

Reference yield:

: (R)-4-Hydroxy-3-[(Z)-1-(3-nitro-phenyl)-propenyl]-6-phenethyl-6-propyl-5,6-dihydro-pyran-2-one

: (R)-4-Hydroxy-3-[(S)-1-(3-nitro-phenyl)-propyl]-6-phenethyl-6-propyl-5,6-dihydro-pyran-2-one

: 215317-22-9
(6R)-4-hydroxy-3-[1-(3-nitrophenyl)-1-propyl]-6-phenethyl-6-propyl-5,6-dihydro-2H-pyran-2-one

Guidance literature:: With hydrogen; 1,2-bis((2R,5R)-2,5-dimethylphospholano)benzene(cyclooctadiene)rhodium(I)tetrafluoroborate; In methanol; at 27 ℃; for 1200h; under 4137.18 Torr;
DOI:10.1021/jo050390d

Reference yield:

: 215317-11-6
(R)-3-(2-phenylethyl)-3-[(4-phenylphenoxy)methoxy]hexanol

: 215317-22-9
(6R)-4-hydroxy-3-[1-(3-nitrophenyl)-1-propyl]-6-phenethyl-6-propyl-5,6-dihydro-2H-pyran-2-one

Guidance literature:: Multi-step reaction with 5 steps

1: 98.6 percent / KBr, NaHCO₃, 4-hydroxy-2,2,6,6-tetramethylpiperidinyloxy, NaOCl / H₂O / 1 h / 1 - 5 °C

2: 89.7 percent / NaHMDS / tetrahydrofuran / -90 - -71 °C

3: 99.2 percent / PCC, NaOAc, Florisil / CH₂Cl₂ / 20 h / Ambient temperature

4: 84.4 percent / H₂SO₄ / methanol; tetrahydrofuran / 22 h / 23 °C

5: 75.1 percent / NaOH / methanol / 67 h / 0 - 5 °C

With sodium hydroxide; sodium hypochlorite; florisil; TEMPOL; sulfuric acid; sodium acetate; sodium hexamethyldisilazane; sodium hydrogencarbonate; pyridinium chlorochromate; potassium bromide; In tetrahydrofuran; methanol; dichloromethane; water;
DOI:10.1021/jo9809229