2155-42-2

Usage

Uses

Used in Polymer and Plastics Industry:
3,5-Dichlorostyrene is used as a monomer for the production of polymers and plastics, contributing to the development of materials with specific properties required for various applications.
Used in Chemical Synthesis:
3,5-Dichlorostyrene is used as a building block in the synthesis of specialty chemicals, enabling the creation of a range of products tailored for different industries.
Used in Adhesives Production:
3,5-Dichlorostyrene is used as a component in the production of adhesives, enhancing their bonding properties and performance in various applications.
Used in Coatings Industry:
3,5-Dichlorostyrene is used as an ingredient in coatings, providing specific characteristics such as durability, resistance, or adhesion, depending on the intended use.
Used in Resins Production:
3,5-Dichlorostyrene is used in the production of resins, which are essential in a variety of applications, including coatings, adhesives, and composite materials.

InChI:InChI=1/C8H6Cl2/c1-2-6-3-7(9)5-8(10)4-6/h2-5H,1H2

Upstream product

• 67-56-1 methanol 
• 93427-13-5 3,5-Dichloro-β-phenethyl alcohol 
• 10203-08-4 3,5-dichlorobenzaldehyde 
• 1779-49-3 Methyltriphenylphosphonium bromide 
• 19752-55-7 1-bromo-3,5-dichlorobenzene 
• 75927-49-0 pinacol vinylboronate 
• 93427-16-8 3,5-Dichloro-β-phenethylsulfonyl chloride 
• 136272-29-2 1-(3,5-dichlorophenyl)-2-(trimethylsilyl)ethanol 
• 136293-63-5 Trifluoro-acetic acid 1-(3,5-dichloro-phenyl)-2-trimethylsilanyl-ethyl ester 
• 70555-56-5 β-(3,5-Dichlorophenyl)ethanesulfonyl azide 

Relevant academic research and scientific papers

Invention of MK-8262, a Cholesteryl Ester Transfer Protein (CETP) Inhibitor Backup to Anacetrapib with Best-in-Class Properties ()

Cholesteryl ester transfer protein (CETP) represents one of the key regulators of the homeostasis of lipid particles, including high-density lipoprotein (HDL) and low-density lipoprotein (LDL) particles. Epidemiological evidence correlates increased HDL and decreased LDL to coronary heart disease (CHD) risk reduction. This relationship is consistent with a clinical outcomes trial of a CETP inhibitor (anacetrapib) combined with standard of care (statin), which led to a 9% additional risk reduction compared to standard of care alone. We discuss here the discovery of MK-8262, a CETP inhibitor with the potential for being the best-in-class molecule. Novel in vitro and in vivo paradigms were integrated to drug discovery to guide optimization informed by a critical understanding of key clinical adverse effect profiles. We present preclinical and clinical evidence of MK-8262 safety and efficacy by means of HDL increase and LDL reduction as biomarkers for reduced CHD risk.

Superbase-Catalyzed anti-Markovnikov Alcohol Addition Reactions to Aryl Alkenes

The organic superbase P4-t-Bu catalyzes the direct anti-Markovnikov addition of alcohols to aryl alkenes to access valuable β-phenethyl ethers. A diverse substrate scope of aryl alkenes and alcohols is demonstrated, including heterocyclic systems and unprotected aminoalcohols. Mechanistic studies reveal that the reaction is under equilibrium control and extensive comparisons to common inorganic bases indicate that the broad reaction scope is uniquely enabled through the use of the organic superbase.

Silicon Effects. VI. β-Silicon Effect of Various Silyl Groups in Solvolysis for α-Alkylbenzyl and α-Silylbenzyl Systems

The kinetic β-silicon effects of various silyl groups including Me3Si, Me3SiMe2Si, (C6H5)Me2Si, (i-PrO)Me2Si, and (CH3OCH2)Me2Si were measured in kc solvolysis of two different benzylic systems of the types, ArCH(OCOCF3)CH2R (3: Ar=phenyl or 3,5-dichlorophenyl, R=silyl group) and C6H5CH(Cl)SiMe2R (4: R=silyl group).The relative β-silyl accelerations were 1.0:5.57:0.309 for R=Me3Si; Me3SiMe2Si, and (C6H5)Me2Si, respectively, for the system 3, and 1.0:7.65:0.502:0.289 for R=Me3Si, Me3SiMe2Si, (i-PrO)Me2Si, and (CH3OCH2)Me2Si, respectively, for the system 4.The variation of the β-silicon effect with γ-substituents was interpreted as reflecting changes in hyperconjugating abilities of β-C-Si and β-Si-Si ?-bonds mainly due to the inductive effect of the γ-substituent groups.

Silicon Effects. II. Structure and Stability of 1-Phenyl-2-(trimethylsilyl)ethyl Cation in Solution

Solvolysis rates have been measured in various solvents at 25 deg C for 1-(substituted phenyl)-2-(trimethylsilyl)ethyl trifluoroacetates (1a - 1g; R=H, 4-Me, 4-Cl, 4-Br, 3-Cl, 3,4-Cl2, and 3,5-Cl2, respectively) and structurally related compounds, 1-phenylethyl-, 3,3-dimethyl-1-phenylbutyl-, and 1-(4-methylphenyl)ethyl trifluoroacetates (3a, 4, and 5).In dioxane/water mixtures 1g solvolyzes with the same sensitivity to the change in solvent ionizing power as that for a kc substrate 5.The solvolyses of 1e and 5 exhibit almost identical α-deuterium kinetic isotope effects (kH/KD) of 1.18 - 1.19 in aq dioxane.Substituent effect on the solvolysis of 1 in 90 percent aq dioxane is expressed by an LArSR equation: log kX/kH = -3.05 (?0 + 1.05 Δ?(mean)+R) (R = 0.9997).These findings are consistent with kc mechanism for the solvolysis of 1.Relative rates for the solvolysis of 1a, 3a, and 4 in 30 percent aq dioxane are 2.99x105:2.84:1.0 indicating solvolytic generation of α-(trimethylsilylmethyl)benzyl cation to be about 7 kcal mol-1 energetically more favorable than that of the corresponding α-alkylbenzyl cations.

Solution and Flash Vacuum Pyrolyses of β-(3,5-Disubstituted-phenyl)ethanesulfonyl Azides. Sultam, Pyrindine, and Azepine Formation

The solution and flash vacuum pyrolyses of β-(3,5-disubstituted-phenyl)ethanesulfonyl azides are reported.When R = Me, FVP results suggest that the substituents stabilize the intermediate leading to the 3,4-dihydro-2,1-benzothiazepine 2,2-dioxide (6a).A n