2155-42-2

Basic information

• Product Name: 3,5-Dichlorostyrene
• Synonyms: 1,3-Dichloro-5-vinylbenzene;3,5-Dichlorostyrene;1,3-dichloro-5-ethenylbenzene
• CAS NO: 2155-42-2
• Molecular Formula: C₈H₆Cl₂
• Molecular Weight: 173.04
• Mol File: 2155-42-2.mol
• Article Data: 5

Chemical Properties

• Melting Point: 48.5°C (estimate)
• Boiling Point: 230.44°C (rough estimate)
• Flash Point: 100.4°C
• Appearance: /
• Density: 1.2250
• Vapor Pressure: 0.0698mmHg at 25°C
• Refractive Index: 1.5745 (estimate)
• CAS DataBase Reference: 3,5-Dichlorostyrene(CAS DataBase Reference)
• NIST Chemistry Reference: 3,5-Dichlorostyrene(2155-42-2)
• EPA Substance Registry System: 3,5-Dichlorostyrene(2155-42-2)

Safety Data

• Hazardous Substances Data: 2155-42-2(Hazardous Substances Data)

Usage

General Description

3,5-Dichlorostyrene is a chemical compound with the molecular formula C8H6Cl2. It is a colorless liquid that is insoluble in water and commonly used in the production of polymers and plastics. 3,5-Dichlorostyrene is often used as a building block for the synthesis of various specialty chemicals and is also used in the production of adhesives, coatings, and resins. It is considered to have low toxicity and is not expected to cause significant harmful effects to human health or the environment. However, proper handling and disposal practices should be followed to minimize any potential risks associated with its use.

InChI:InChI=1/C8H6Cl2/c1-2-6-3-7(9)5-8(10)4-6/h2-5H,1H2

Upstream product

• 136293-63-5 Trifluoro-acetic acid 1-(3,5-dichloro-phenyl)-2-trimethylsilanyl-ethyl ester 
• 10203-08-4 3,5-dichlorobenzaldehyde 
• 1779-49-3 Methyltriphenylphosphonium bromide 
• 19752-55-7 1-bromo-3,5-dichlorobenzene 
• 75927-49-0 pinacol vinylboronate 
• 93427-16-8 3,5-Dichloro-β-phenethylsulfonyl chloride 
• 93427-13-5 3,5-Dichloro-β-phenethyl alcohol 
• 136272-29-2 1-(3,5-dichlorophenyl)-2-(trimethylsilyl)ethanol 
• 70555-56-5 β-(3,5-Dichlorophenyl)ethanesulfonyl azide 
• 67-56-1 methanol 

Relevant articles and documents

Invention of MK-8262, a Cholesteryl Ester Transfer Protein (CETP) Inhibitor Backup to Anacetrapib with Best-in-Class Properties ()

Cholesteryl ester transfer protein (CETP) represents one of the key regulators of the homeostasis of lipid particles, including high-density lipoprotein (HDL) and low-density lipoprotein (LDL) particles. Epidemiological evidence correlates increased HDL and decreased LDL to coronary heart disease (CHD) risk reduction. This relationship is consistent with a clinical outcomes trial of a CETP inhibitor (anacetrapib) combined with standard of care (statin), which led to a 9% additional risk reduction compared to standard of care alone. We discuss here the discovery of MK-8262, a CETP inhibitor with the potential for being the best-in-class molecule. Novel in vitro and in vivo paradigms were integrated to drug discovery to guide optimization informed by a critical understanding of key clinical adverse effect profiles. We present preclinical and clinical evidence of MK-8262 safety and efficacy by means of HDL increase and LDL reduction as biomarkers for reduced CHD risk.

Silicon Effects. VI. β-Silicon Effect of Various Silyl Groups in Solvolysis for α-Alkylbenzyl and α-Silylbenzyl Systems

The kinetic β-silicon effects of various silyl groups including Me3Si, Me3SiMe2Si, (C6H5)Me2Si, (i-PrO)Me2Si, and (CH3OCH2)Me2Si were measured in kc solvolysis of two different benzylic systems of the types, ArCH(OCOCF3)CH2R (3: Ar=phenyl or 3,5-dichlorophenyl, R=silyl group) and C6H5CH(Cl)SiMe2R (4: R=silyl group).The relative β-silyl accelerations were 1.0:5.57:0.309 for R=Me3Si; Me3SiMe2Si, and (C6H5)Me2Si, respectively, for the system 3, and 1.0:7.65:0.502:0.289 for R=Me3Si, Me3SiMe2Si, (i-PrO)Me2Si, and (CH3OCH2)Me2Si, respectively, for the system 4.The variation of the β-silicon effect with γ-substituents was interpreted as reflecting changes in hyperconjugating abilities of β-C-Si and β-Si-Si ?-bonds mainly due to the inductive effect of the γ-substituent groups.

Solution and Flash Vacuum Pyrolyses of β-(3,5-Disubstituted-phenyl)ethanesulfonyl Azides. Sultam, Pyrindine, and Azepine Formation

The solution and flash vacuum pyrolyses of β-(3,5-disubstituted-phenyl)ethanesulfonyl azides are reported.When R = Me, FVP results suggest that the substituents stabilize the intermediate leading to the 3,4-dihydro-2,1-benzothiazepine 2,2-dioxide (6a).A n