215512-32-6

Upstream product

• 108-30-5 succinic acid anhydride 
• 215512-31-5 [(S)-1-((S)-1-{(S)-1-[(S)-5-Benzyloxycarbonylamino-1-((1S,2R)-2-hydroxy-indan-1-ylcarbamoyl)-pentylcarbamoyl]-2-phenyl-ethylcarbamoyl}-2-phenyl-ethylcarbamoyl)-5-(9H-fluoren-9-ylmethoxycarbonylamino)-pentyl]-carbamic acid tert-butyl ester 

Downstream Products

• 215511-39-0 [(2S,5S,8S,23S)-2,5-Dibenzyl-8-((1S,2R)-2-hydroxy-indan-1-ylcarbamoyl)-3,6,14,17,24-pentaoxo-1,4,7,13,18-pentaaza-cyclotetracos-23-yl]-carbamic acid tert-butyl ester 
• 1025993-54-7 N-[(S)-5-((S)-1-{(S)-1-[(S)-5-Amino-1-((1S,2R)-2-hydroxy-indan-1-ylcarbamoyl)-pentylcarbamoyl]-2-phenyl-ethylcarbamoyl}-2-phenyl-ethylcarbamoyl)-5-tert-butoxycarbonylamino-pentyl]-succinamic acid 

Relevant academic research and scientific papers

Synthesis and activity of HIV protease inhibitors

We report here the synthesis and activity of HIV protease inhibitors. In the first stage hydrophobic compounds incorporating a 'carba' bond surrogate or a beta-homologated residue were synthesized. Secondly, we synthesized cyclic compounds in which we incorporated 2-quinoline carboxylic acid in the P3 position and the amino-hydroxyindane moiety in the P'3. The last part of this work was dedicated to a structure/activity study of a peptide substrate. These modifications allowed us to work up the synthesis of new pseudopeptide bonds: amino-amide and hydroxy-amide. Compounds with activity in the micromolar range were actually a starting point for the synthesis of new protease inhibitors.