215797-98-1

Upstream product

• 81445-44-5 (S)-2-(benzyloxy)propanal 
• 96837-44-4 (R)-4-isopropyl-3-(3-phenylpropanoyl)oxazolidin-2-one 
• 645-45-4 hydrocinnamic acid chloride 
• 95530-58-8 (R)-4-isopropyloxazolidin-2-one 

Downstream Products

• 215798-07-5 (2R,3R,4S)-2-benzyl-3-hydroxy-4-benzyloxypentanoic acid 
• 186528-21-2 (3R,4R,5S)-3-benzyl-4-hydroxy-5-methyldihydrofuran-2(3H)-one 
• 215798-01-9 (3R,4R,5S)-3-benzyl-4-(tert-butyldimethylsilanyloxy)-5-methyldihydrofuran-2-one 
• 215797-96-9 (2R,3R,4S)-2-benzyl-3-(tert-butyldimethylsilanyloxy)-4-benzyloxypentanoic acid 
• 215797-95-8 (2R,3R,4S)-2-benzyl-3-(tert-butyldimethylsilanyloxy)-4-hydroxypentanoic acid (2S)-2-tert-butoxycarbonylamino-2-carboxyethyl ester 
• 215797-99-2 (2R,3R,4S)-2-Benzyl-4-benzyloxy-3-(tert-butyl-dimethyl-silanyloxy)-pentanoic acid (S)-2-benzyloxycarbonyl-2-tert-butoxycarbonylamino-ethyl ester 

Relevant academic research and scientific papers

Total synthesis of the antifungal dilactones UK-2A and UK-3A: The determination of their relative and absolute configurations, analog synthesis and antifungal activities

The synthesis of the antifungal dilactones, UK-2A and UK-3A, is described. In addition to providing a workable synthetic route to these potent antifungal antibiotics, this has allowed us to determine the assignment of the relative and absolute configurations in the nine-membered ring. Furthermore, UK-2A analogs were also synthesized and evaluated their antifungal activities and cytotoxic activities along with UK-2A, (2R, 3R, 4S, 7R)-UK-2A, UK-3A, (2R, 3R, 4S, 7R)-UK-3A, and antimycin A. The structural requirements for the selective cytotoxicity against yeasts and filamentous fungi will also be suggested.