Tetrahedron p. 12745 - 12774 (1998)
Update date:2022-08-03
Topics: Retrosynthetic analysis Purification and characterization Scale-up and optimization Structure-Activity Relationship (SAR) Studies Stereochemical Control Synthesis of Key Intermediates Analog Synthesis
Shimano, Masanao
Kamei, Noriyuki
Shibata, Tetsuo
Inoguchi, Kiyoshi
Itoh, Nobuko
Ikari, Takashi
Senda, Hisato
The synthesis of the antifungal dilactones, UK-2A and UK-3A, is described. In addition to providing a workable synthetic route to these potent antifungal antibiotics, this has allowed us to determine the assignment of the relative and absolute configurations in the nine-membered ring. Furthermore, UK-2A analogs were also synthesized and evaluated their antifungal activities and cytotoxic activities along with UK-2A, (2R, 3R, 4S, 7R)-UK-2A, UK-3A, (2R, 3R, 4S, 7R)-UK-3A, and antimycin A. The structural requirements for the selective cytotoxicity against yeasts and filamentous fungi will also be suggested.
View MoreContact:+86 21 5017 5386
Address:No 999,Jiangyue Rd, Minhang Dist ,201114,Shanghai ,China
SHANGHAI RC CHEMICALS CO.,LTD.
website:http://www.rcc.net.cn
Contact:+86-21-50322175
Address:Rm1415 Yinqiao Masion No.58 Jinxin Road Pudong Shanghai China
Contact:410-273-7300; 800-221-3953
Address:4609 Richlynn Dr., PO Box 369, Belcamp, MD, 21017-0369, USA
Shanghai Send Pharmaceutical Technology Co., Ltd.
website:http://www.shsendpharma.com
Contact:021-58088081, +8613585868794
Address::Room A601, Building 1,NO. 800 Qingdai Road Pudong District Shanghai,China
hangzhou verychem science and technology co.ltd
website:http://www.verypharm.com
Contact:+86-571-88162785; 88162786
Address:F1502, 753 Shenhua road, Hangzhou, China
Doi:10.1021/ja982172q
(1998)Doi:10.1021/jm4006324
(2013)Doi:10.1016/S0020-1693(98)00215-1
(1998)Doi:10.1021/ic50027a013
(1965)Doi:10.1021/jo00184a022
(1984)Doi:10.1246/bcsj.41.2964
(1968)
