215999-35-2

Upstream product

• 118-93-4 o-hydroxyacetophenone 
• 201230-82-2 carbon monoxide 
• 104-95-0 (4-bromophenyl)thioanisole 
• 3446-89-7 4-(Methylthio)benzaldehyde 
• 936372-02-0 (E)-1-(2-Hydroxy-phenyl)-3-(4-methylsulfanyl-phenyl)-propenone 

Downstream Products

• 215999-43-2 3-bromo-2-(4-(methylthio)phenyl)-4H-1-benzopyran-4-one 
• 259679-69-1 2-(4-(methylsulfonyl)phenyl)-3-(3-pyridinyl)-4H-1-benzopyran-4-one 
• 259681-69-1 3-iodo-2-(4-(methylsulfonyl)phenyl)-4H-1-benzopyran-4-one 
• 215999-44-3 3-bromo-2-(4-(methylsulfonyl)phenyl)-4H-1-benzopyran-4-one 
• 215999-46-5 3-bromo-4'-methylsulfinylflavone 
• 215999-36-3 2-(4-methanesulfonyl-phenyl)-chromen-4-one 

Relevant academic research and scientific papers

Palladium-catalyzed carbonylation reaction of aryl bromides with 2-hydroxyacetophenones to form flavones

Flavone of the month: A general and efficient method for the palladium-catalyzed carbonylative synthesis of flavones has been developed (see scheme). Starting from aryl bromides and 2-hydroxyacetophenones, the corresponding flavones have been isolated in good yields. Copyright

Ionic liquid mediated Cu-catalyzed cascade oxa-Michael-oxidation: Efficient synthesis of flavones under mild reaction conditions

Flavonoids are a class of natural products, found in a wide range of vascular plants and dietary components. Their low toxicity and extensive biological activities, including anti-cancer and anti-bacterial, have made them attractive candidates to serve as therapeutic agents for many diseases. Herein, we disclose a highly efficient synthetic method of CuI-catalyzed cascade oxa-Michael-oxidation, using chalcones as substrates, mediated by the ionic liquid [bmim][NTf2] at a low temperature. This efficient synthetic method has demonstrated high synthetic utility and can afford flavones in good to high yields (up to 98%).

2,3-Diarylbenzopyran derivatives as a novel class of selective cyclooxygenase-2 inhibitors

A new series of cyclooxygenase-2(COX-2) inhibitors with naturally occurring flavone as the main skeleton has been synthesized and their biological activities were evaluated for cyclooxygenase inhibitory activity. Rational structural modifications were applied to potent COX-2 inhibitors to obtain the desired pharmacokinetic profiles for improved oral anti-inflammatory activity.

Diarylbenzopyran derivatives as cyclooxygenase-2 inhibitors

The diarylbenzopyran derivatives represented by formula I, and the pharmaceutically acceptable salts thereof, are disclosed. The composition comprising the compound of formula I, or a pharmaceutically acceptable salt thereof, shows an excellent selective inhibition of cyclooxygenase-2.