259679-69-1

Upstream product

• 215999-44-3 3-bromo-2-(4-(methylsulfonyl)phenyl)-4H-1-benzopyran-4-one 
• 118-93-4 o-hydroxyacetophenone 
• 3446-89-7 4-(Methylthio)benzaldehyde 
• 215999-35-2 (4-(methylthio)phenyl)-4H-1-benzopyran-4-one 
• 215999-43-2 3-bromo-2-(4-(methylthio)phenyl)-4H-1-benzopyran-4-one 
• 936372-02-0 (E)-1-(2-Hydroxy-phenyl)-3-(4-methylsulfanyl-phenyl)-propenone 

Relevant academic research and scientific papers

2,3-Diarylbenzopyran derivatives as a novel class of selective cyclooxygenase-2 inhibitors

A new series of cyclooxygenase-2(COX-2) inhibitors with naturally occurring flavone as the main skeleton has been synthesized and their biological activities were evaluated for cyclooxygenase inhibitory activity. Rational structural modifications were applied to potent COX-2 inhibitors to obtain the desired pharmacokinetic profiles for improved oral anti-inflammatory activity.