936372-02-0

Basic information

• Product Name: (E)-1-(2-Hydroxy-phenyl)-3-(4-methylsulfanyl-phenyl)-propenone
• Synonyms: (E)-1-(2-Hydroxy-phenyl)-3-(4-methylsulfanyl-phenyl)-propenone
• CAS NO: 936372-02-0
• Molecular Weight: 270.352
• Mol File: 936372-02-0.mol

Chemical Properties

• CAS DataBase Reference: (E)-1-(2-Hydroxy-phenyl)-3-(4-methylsulfanyl-phenyl)-propenone(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-1-(2-Hydroxy-phenyl)-3-(4-methylsulfanyl-phenyl)-propenone(936372-02-0)
• EPA Substance Registry System: (E)-1-(2-Hydroxy-phenyl)-3-(4-methylsulfanyl-phenyl)-propenone(936372-02-0)

Safety Data

• Hazardous Substances Data: 936372-02-0(Hazardous Substances Data)

Upstream product

• 118-93-4 o-hydroxyacetophenone 
• 3446-89-7 4-(Methylthio)benzaldehyde 

Downstream Products

• 259679-69-1 2-(4-(methylsulfonyl)phenyl)-3-(3-pyridinyl)-4H-1-benzopyran-4-one 
• 259681-69-1 3-iodo-2-(4-(methylsulfonyl)phenyl)-4H-1-benzopyran-4-one 
• 215999-44-3 3-bromo-2-(4-(methylsulfonyl)phenyl)-4H-1-benzopyran-4-one 
• 215999-46-5 3-bromo-4'-methylsulfinylflavone 
• 215999-36-3 2-(4-methanesulfonyl-phenyl)-chromen-4-one 
• 215999-43-2 3-bromo-2-(4-(methylthio)phenyl)-4H-1-benzopyran-4-one 
• 215999-35-2 (4-(methylthio)phenyl)-4H-1-benzopyran-4-one 

Relevant articles and documents

Synthesis, antimycobacterial activity evaluation, and QSAR studies of chalcone derivatives

In order to develop relatively small molecules as antimycobacterial agents, twenty-five chalcones were synthesized, their activity was evaluated, and quantitative structure-activity relationship (QSAR) was developed. The synthesis was based on the Claisen

Inhibitory activity of prostaglandin E2 production by the synthetic 2′-hydroxychalcone analogues: Synthesis and SAR study

A series of 2′-hydroxychalcones has been synthesized and screened for their in vitro inhibitory activities of cyclooxygenase-2 catalyzed prostaglandin production from lipopolysaccharide-treated RAW 264.7 cells. Structure-activity relationship study suggested that inhibitory activity against prostaglandin E2 production was governed to a greater extent by the substituent on B ring of the chalcone, and most of the active compounds have at least two methoxy or benzyloxy groups on B ring. The relationship between chalcone structures and their PGE2 inhibitory activities was also interpreted by docking study on cyclooxygenase-2.

Synthetic chalcones, flavanones, and flavones as antitumoral agents: Biological evaluation and structure-activity relationships

A series of synthetic chalcones, flavanones, and flavones has been synthesized and evaluated for antitumor activity against the human kidney carcinoma cells TK-10, human mammary adenocarcinoma cells MCF-7 (estrogen receptor-positive), and human colon adenocarcinoma cells HT-29. The most active series is the chalcone ones with the best results against TK-10 and HT-29 cells. Fourteen out of 53 analyzed compounds resulted very active against at least two of the studied tumoral cells. Alkaline single cell gel electrophoresis, comet assay, was performed as a study of the chromosomal aberrations promoted by the compounds on normal cells. Four active and two inactive chalcones were studied in the comet assay against normal human kidney cells (HK-2). A structure-activity relationship analysis of these compounds was performed and for 4- and 3,4-disubstituted derivatives a quantitative correlation was obtained in the case of anti-HT-29 activity.

2,3-Diarylbenzopyran derivatives as a novel class of selective cyclooxygenase-2 inhibitors

A new series of cyclooxygenase-2(COX-2) inhibitors with naturally occurring flavone as the main skeleton has been synthesized and their biological activities were evaluated for cyclooxygenase inhibitory activity. Rational structural modifications were applied to potent COX-2 inhibitors to obtain the desired pharmacokinetic profiles for improved oral anti-inflammatory activity.