42783-78-8Relevant academic research and scientific papers
Synthesis of three selectively deuterated propylene oxides
Otley, Kate D.,Saccomano, Benjamin W.,McKee, Silas A.,Nizialek, Gregory A.,Hamilton, David S.,Sherrow, Leighanne K.,Jones, Camille Y.,Rosenstein, Ian J.
scheme or table, p. 308 - 311 (2012/02/03)
Three different selectively deuterated propylene oxides have been synthesized for use in quasi-elastic neutron scattering studies of the dynamics of propylene oxide within clathrate hydrate cages. Copyright 2011 John Wiley & Sons, Ltd. Three different selectively deuterated propylene oxides have been synthesized for use in quasi-elastic neutron scattering studies of the dynamics of propylene oxide within clathrate hydrate cages. Copyright
Process for Manufacture of Optically Active 2-(Acyloxymethyl)-1,3-Oxathiolanes
-
, (2010/06/19)
There is provided a process for manufacture of optically-active, 2-(acyloxymethyl)-1,3-oxathiolanes of Formula I comprising a preparation of a racemic compound and an enzyme-catalyzed kinetic resolution of the enantiomers. The invention may further provide for the esterification and racemization of the by-product of the enzymatic reaction. In this manner, 2(R)-(benzoyloxymethyl)-1,3-oxathiolane is prepared as a useful intermediate for manufacture of the anti-HIV drug Apricitabine.
Synthesis and biological evaluation of 3-hydroxymethylpyrimido[1,6-c][1,3]oxazine derivatives
Hsu, Ling-Yih,Lin, Chung-Hsun
, p. 2687 - 2699 (2007/10/03)
A number of 5-substituted 3-hydroxymethylpyrimido[1,6-c] [1,3]-oxazine derivatives were synthesized and evaluated for their biological activity. Compound (10) showed slight activity (GI50 = 2.7 μM) against MDA-MB-231/ATTC Breast Cancer cell line.
COBALT-MEDIATED ALKYLATION OF SILOXY FURANS
Stuart, John G.,Nicholas, Kenneth M.
, p. 949 - 963 (2007/10/02)
Dicobalt hexacarbonyl complexes of propargylium and α-vinylpropargylium cations couple efficiently with 2-trimethylsiloxyfuran (5), 4-trimethylsilyloxy-2-benzyloxymethylfuran (15) and 2-trimethylsilyl-3-trimethylsilyloxy-4-ethylbenzofuran (20) to produce the corresponding complexed furan derivatives in good yields.A convenient procedure for introducing the 2,4-enyne moiety regio- and stereoselectively into the above heterocycles using this methodology is described.
Analogues of the Antiviral Acyclonucleoside 9-(4-Hydroxy-3-hydroxymethylbutyl)guanine. Part 1. Substitutions on C-2' of the Acyclic N-9 Substituent
Harnden, Michael R.,Parkin, Ann,Wyatt, Paul G.
, p. 2757 - 2766 (2007/10/02)
Syntheses of 9-(4-hydroxy-3-hydroxymethyl-2-methylbutyl)guanine (4), 9-(4-hydroxy-3-hydroxymethyl-2-methoxybutyl)guanine (5), 9-guanine (6), 9-(2,4-dihydroxy-3-hydroxymethylbutyl)guanine (7), and 9-(2-fluoro-4-hydrox
Degradation Pathway of Arylglycerol-β-aryl Ethers by Phanerochaete chrysosporium
Umezawa, Toshiaki,Nakatsubo, Fumiaki,Higuchi, Takayoshi
, p. 2677 - 2682 (2007/10/02)
The degradation pathway for the most important β-O-4 lignin substructure with a white rot fungus, Phanerochaete chrysosporium, was investigated, and the following conclusions were obtained. a) The allyl alcohol end group attached to the β-O-4 substructure was degraded to a formyl group via a glycerol group. b) Arylglycerol was formed by the cleavage of the β-O-4 substructure without involvement of the hydroxylation reaction at Cβ. c) 18O was not incorporated from 18O2 into arylglycerol nor phenol liberated by the degradation of the β-O-4 substrucrure, but was incorporated into the benzyl alcohol derivative formed by Cα-Cβ cleavage. d( Two alternative degradation pathway of the β-O-4 substructure, a pathway via arylglycerol and direct oxygenative Cα-Cβ cleavage, are proposed
