216168-29-5Relevant academic research and scientific papers
Discovery of novel phenolic antioxidants as inhibitors of vascular cell adhesion molecule-1 expression for use in chronic inflammatory diseases
Meng, Charles Q.,Somers, Patricia K.,Hoong, Lee K.,Zheng, X. Sharon,Ye, Zhihong,Worsencroft, Kimberly J.,Simpson, Jacob E.,Hotema, Martha R.,Weingarten, M. David,MacDonald, Mathew L.,Hill, Russell R.,Marino, Elaine M.,Suen, Ki-Ling,Luchoomun, Jayraz,Kunsch, Charles,Landers, Laura K.,Stefanopoulos, Dimitria,Howard, Randy B.,Sundell, Cynthia L.,Saxena, Uday,Wasserman, Martin A.,Sikorski, James A.
, p. 6420 - 6432 (2007/10/03)
Vascular cell adhesion molecule-1 (VCAM-1) mediates recruitment of leukocytes to endothelial cells and is implicated in many inflammatory conditions. Since part of the signal transduction pathway that regulates the activation of VCAM-1 expression is redox
Compounds and methods for the inhibition of the expression of VCAM-1
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, (2008/06/13)
This invention is in the area of methods and compositions for the inhibition of the expression of VCAM-1 and, in particular, for the treatment of diseases mediated by VCAM-1, including cardiovascular and inflammatory diseases.
