216168-45-5

Usage

Uses

Used in Pharmaceutical Industry:
Probucol Disuccinate is used as a pharmaceutical agent for the treatment of coronary artery disease. It helps in lowering the levels of HDL cholesterol, which is beneficial in managing the condition.
Used in Cardiovascular Health:
Probucol Disuccinate is used as a cardiovascular health supplement to maintain healthy cholesterol levels. Its ability to lower HDL cholesterol levels makes it a potential candidate for managing and preventing cardiovascular diseases.

Upstream product

• 108-30-5 succinic acid anhydride 
• 23288-49-5 (4,4'-isopropylidenedithio)bis[2,6-di-tert-butylphenol] 

Relevant academic research and scientific papers

PROCESS FOR ISOLATING MONO-CARBOXY SUBSTITUTED PROBUCOL DERIVATES

A process for isolating a compound of formula (I) or a salt thereof, where X and R1 are as defined in the specification, from a mixture containing it, and the corresponding diacid and dihydroxy derivative, said process comprising (i) adding to an organic

Process for preparation of probucol derivatives

A method is described for the preparation of polymorphic forms of water-soluble derivatives of probucol compounds having the following formula where R1, R2, R3, R4, R5, R6, and Z′ are defined herein.

PROCESS FOR THE SEPARATION OF PROBUCOL DERIVATIVES

Provided are methods for the separation of mono-substituted probucol derivatives from a mixture of both mono- and di-substituted probucol derivatives. In particular, methods are provided for the separation of mono-carboxy substituted probucol derivatives

Process for preparation of probucol derivatives

A method is described for the preparation of polymorphic forms of water-soluble derivatives of probucol compounds having the following formula where R1, R2, R3, R4, R5, R6, Z and Z′ are defined herein.

Process of preparing esters and ethers of probucol and derivatives thereof

Provided are methods for manufacturing compounds of Formula I wherein all substituents are described herein.

Process for preparation of probucol derivatives

A method is described for the preparation of polymorphic forms of water-soluble derivatives of probucol compounds having the following formula where R1, R2, R3, R4, R5, R6, Z and Z′ are defined herein.

PROCESS OF PREPARING ESTERS AND ETHERS OF PROBUCOL AND DERIVATIVES THEREOF

Provided are methods for manufacturing compounds of Formula I wherein all substituents are described herein.

Novel phenolic antioxidants as multifunctional inhibitors of inducible VCAM-1 expression for use in atherosclerosis

A series of novel phenolic compounds has been discovered as potent inhibitors of TNF-α-inducible expression of vascular cell adhesion molecule-1 (VCAM-1) with concurrent antioxidant and lipid-modulating properties. Optimization of these multifunctional agents led to the identification of 3a (AGI-1067) as a clinical candidate with demonstrated efficacies in animal models of atherosclerosis and hyperlipidemia.