216306-29-5Relevant academic research and scientific papers
High asymmetric induction in anionic amino-cope rearrangements controlled by β-aminoalcohol auxiliaries
Allin, Steven M.,Button, Martin A. C.,Baird, Robert D.
, p. 1117 - 1119 (1998)
Novel 3-amino-1,5-dienes were prepared with high diastereoselectivity by unprecedented 1,2-addition of allyl Grignard to α,β-unsaturated imines containing β-aminoalcohol auxiliaries. Asymmetric anionic amino-Cope rearrangement of the diastereoisomerically pure 3-amino-1,5-diene substrates proceeded to yield the target 3-substituted aldehyde in good yield and with high levels of asymmetric induction (up to 94% e.e.).
