21631-82-3

Upstream product

• 61762-39-8 N-tetradecanoyl-1,2-ethylenediamine 
• 544-63-8 n-tetradecanoic acid 
• 107-15-3 ethylenediamine 
• 88097-29-4 2-Tridecyl-1,4,5,6-tetrahydro-pyrimidine 
• 5136-46-9 N,N'-ethanediyl-bis-myristamide 
• 6780-13-8 1,2-ethanediamine monohydrate 
• 626-29-9 myristic anhydride 

Relevant academic research and scientific papers

Pulsatile release from pH triggered imidazoline switchable surfactant liposomes

The incorporation of an imidazoline (IDZ) based switchable surfactant into the lipid membrane of a liposome produces a system that can be triggered to release its solute upon pH change. However, unlike traditional pH-triggered controlled release systems, IDZ-liposomes are capable of undergoing multiple triggering events, resulting in solute release in a pulsatile manner. Furthermore near-total release can be achieved incrementally with temporal control. A mechanism for this reversible behaviour is also proposed, and dependence on the physical properties of the surfactant is discussed.

Compositions and method comprising heterocyclic compounds containing two heteroatoms

A method and compositions for topically administering physiologically active agents through the skin and mucous membranes of humans and animals in a transdermal device or formulation for systemic use or to the skin of humans and animals for localized use comprising applying to such skin or membrane a mixture of said physiologically active agent and a non-toxic, effective penetrating amount of penetration enhancing compound having the structural formula I: STR1 wherein: R is a saturated or unsaturated hydrocarbon group with from 5 to 19 carbon atoms; R' and R" are hydrogen, lower alkyl, trifluoromethyl, lower hydroxyalkyl or lower alkyl ester of lower hydroxyalkyl, with the proviso that both R' and R" are not lower hydroxyalkyl; X is O or NR1 ; R1 being hydrogen, lower alkyl, lower alkenyl, lower hydroxyalkyl or lower alkyl ester of lower hydroxyalkyl are disclosed.

Rapid Synthesis and Interconversions of Fatty 4,5-Dihydroimidazoles and Fatty 1,4,5,6-Tetrahydropyrimidines. Thermal Cyclizations of Fatty Amides Involving Phenyl Phosphorodiamidate

Brief heating of ethane-1,2- and propane-1,3-bis-fatty amides at 235-250 deg C with phenyl phosphorodiamidate gave routes to high yields of 2-fatty alkyl-4,5-dihydroimidazoles and 1,4,5,6-tetrahydropyrimidines.Ready interconversions of fatty dihydroimidazoles and tetrahydropyrimidines, involving diamine exchange with solvent, were observed on brief heating of these materials in ethylenediamine and trimethylenediamine as solvents.