216317-64-5

Basic information

• Product Name: ETHYL 3-(6-CHLORO-3-PYRIDYL)-3-OXOPROPANOATE
• Synonyms: ETHYL 3-(6-CHLORO-3-PYRIDYL)-3-OXOPROPANOATE;ethyl 3-(6-chloropyridin-3-yl)-3-oxopropanoate
• CAS NO: 216317-64-5
• Molecular Formula: C₁₀H₁₀ClNO₃
• Molecular Weight: 227.646
• Mol File: 216317-64-5.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 346.313 °C at 760 mmHg
• Flash Point: 163.244 °C
• Appearance: /
• Density: 1.271 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.525
• Storage Temp.: 2-8°C
• PKA: 9.18±0.48(Predicted)
• CAS DataBase Reference: ETHYL 3-(6-CHLORO-3-PYRIDYL)-3-OXOPROPANOATE(CAS DataBase Reference)
• NIST Chemistry Reference: ETHYL 3-(6-CHLORO-3-PYRIDYL)-3-OXOPROPANOATE(216317-64-5)
• EPA Substance Registry System: ETHYL 3-(6-CHLORO-3-PYRIDYL)-3-OXOPROPANOATE(216317-64-5)

Safety Data

• Hazardous Substances Data: 216317-64-5(Hazardous Substances Data)

Usage

General Description

ETHYL 3-(6-CHLORO-3-PYRIDYL)-3-OXOPROPANOATE is a chemical compound with the molecular formula C10H10ClNO3. It is commonly used as an intermediate in the synthesis of various pharmaceuticals and agrochemicals. ETHYL 3-(6-CHLORO-3-PYRIDYL)-3-OXOPROPANOATE is known for its potential as an inhibitor of the enzyme acetylcholinesterase, which plays a crucial role in the transmission of nerve impulses. It is also used as an active ingredient in certain insecticides and herbicides. This chemical is considered to be toxic if ingested or inhaled and can cause irritation to the skin and eyes. Overall, ETHYL 3-(6-CHLORO-3-PYRIDYL)-3-OXOPROPANOATE has important applications in the fields of medicine and agriculture, but proper safety measures should be taken when handling it.

InChI:InChI=1/C10H10ClNO3/c1-2-15-10(14)5-8(13)7-3-4-9(11)12-6-7/h3-4,6H,2,5H2,1H3

Upstream product

• 58757-38-3 6-Chloronicotinoyl chloride 
• 6148-64-7 ethyl potassium malonate 
• 33252-28-7 6-chloronicotinonitrile 
• 105-36-2 ethyl bromoacetate 
• 1071-46-1 hydrogen ethyl malonate 
• 23100-12-1 6-chloronicotinylaldehyde 
• 350229-56-0 ethyl 3-[3-(6-chloropyridyl)]-3-hydroxypropanoate 

Downstream Products

• 55676-22-7 3-acetyl-6-chloropyridine 
• 350229-55-9 ethyl (+/-)-2-[3-(6-chloropyridyl)]-4-oxo-2-cyclohexene-1-carboxylate 

Relevant articles and documents

PHARMACEUTICAL COMPOUNDS

Benzodiazepine derivatives of formula (I): (I) wherein: each of R1 and R2 is independently H or halo; either (i) T is N, Z is C, ---a--- and ---c--- are bonds, and ---b--- and ---d--- are absent; or (ii) T is C, Z is N, ---b--- and ---d--- are bonds, and ---a--- and ---c--- are absent; each of R3 and R4 is independently halo, -OR6, -NR6R7, -COR8, -C(O)OR8, -CON(R8)2 or -R6; R5 is H or halo; each of R6 and R7 is independently H or a group selected from C1-C6 alkyl, C3-C10 cycloalkyl, C6-C10 aryl, 4- to 10-membered heterocyclyl and 4- to 10-membered heteroaryl, the group being unsubstituted or substituted; R8 is H or C1-C6 alkyl, each R8 being the same or different when two are present; n is 0 or 1; and one of V, W, X and Y is N or CH and the other three are CH; and the pharmaceutically acceptable salts thereof are inhibitors of RSV and can therefore be used to treat or prevent an RSV infection.

Reformatsky and Blaise reactions in flow as a tool for drug discovery. One pot diversity oriented synthesis of valuable intermediates and heterocycles

The application of Reformatsky and Blaise reactions for the preparation of a diverse set of valuable intermediates and heterocycles in a one-pot protocol is described. To achieve this goal, a greener activation protocol for zinc in flow conditions has been developed to introduce this metal efficiently into α-bromoacetates. The organozinc compounds were added to a diverse set of ketones and nitriles to obtain a wide range of functional groups and heterocyclic systems.

PROCESS FOR PRODUCTION OF 2,3'-BIPYRIDYL-6'-ONE

A production process where 2,3'-bipyridyl-6'-one can be produced in high purity at low cost on an industrial scale without using an expensive catalyst or special equipment is provided. A process for producing 2,3'-bipyridyl-6'-one comprises reacting an acetylpyridine derivative with at least one of compounds represented by formulae (II) to (V) to synthesize a bipyridine derivative and hydrolyzing the bipyridine derivative by one-pot preparation. In formulae (II) to (V), each of R2 to R8, X and Y represents a given group.