216317-64-5

Usage

Uses

Used in Pharmaceutical Industry:
ETHYL 3-(6-CHLORO-3-PYRIDYL)-3-OXOPROPANOATE is used as a chemical intermediate for the synthesis of various pharmaceuticals, contributing to the development of new medications due to its unique chemical properties.
Used in Agrochemical Industry:
In the agrochemical sector, ETHYL 3-(6-CHLORO-3-PYRIDYL)-3-OXOPROPANOATE is utilized as an active ingredient in certain insecticides and herbicides, leveraging its ability to inhibit acetylcholinesterase and control pests and weeds in agricultural settings.
Used as an Acetylcholinesterase Inhibitor:
ETHYL 3-(6-CHLORO-3-PYRIDYL)-3-OXOPROPANOATE is used as an enzyme inhibitor for acetylcholinesterase, playing a significant role in the transmission of nerve impulses, which is a key mechanism in both medical and agricultural applications.
Safety Considerations:
ETHYL 3-(6-CHLORO-3-PYRIDYL)-3-OXOPROPANOATE is considered toxic if ingested or inhaled and can cause skin and eye irritation. Therefore, it is crucial to implement proper safety measures when handling this chemical to prevent adverse health effects.

InChI:InChI=1/C10H10ClNO3/c1-2-15-10(14)5-8(13)7-3-4-9(11)12-6-7/h3-4,6H,2,5H2,1H3

Upstream product

• 23100-12-1 6-chloronicotinylaldehyde 
• 58757-38-3 6-Chloronicotinoyl chloride 
• 6148-64-7 ethyl potassium malonate 
• 1071-46-1 hydrogen ethyl malonate 
• 33252-28-7 6-chloronicotinonitrile 
• 105-36-2 ethyl bromoacetate 
• 350229-56-0 ethyl 3-[3-(6-chloropyridyl)]-3-hydroxypropanoate 

Downstream Products

• 55676-22-7 3-acetyl-6-chloropyridine 
• 350229-55-9 ethyl (+/-)-2-[3-(6-chloropyridyl)]-4-oxo-2-cyclohexene-1-carboxylate 

Relevant academic research and scientific papers

PHARMACEUTICAL COMPOUNDS

Benzodiazepine derivatives of formula (I): (I) wherein: each of R1 and R2 is independently H or halo; either (i) T is N, Z is C, ---a--- and ---c--- are bonds, and ---b--- and ---d--- are absent; or (ii) T is C, Z is N, ---b--- and ---d--- are bonds, and ---a--- and ---c--- are absent; each of R3 and R4 is independently halo, -OR6, -NR6R7, -COR8, -C(O)OR8, -CON(R8)2 or -R6; R5 is H or halo; each of R6 and R7 is independently H or a group selected from C1-C6 alkyl, C3-C10 cycloalkyl, C6-C10 aryl, 4- to 10-membered heterocyclyl and 4- to 10-membered heteroaryl, the group being unsubstituted or substituted; R8 is H or C1-C6 alkyl, each R8 being the same or different when two are present; n is 0 or 1; and one of V, W, X and Y is N or CH and the other three are CH; and the pharmaceutically acceptable salts thereof are inhibitors of RSV and can therefore be used to treat or prevent an RSV infection.

ISOXAZOLE DERIVATIVE AS MUTATED ISOCITRATE DEHYDROGENASE 1 INHIBITOR

It has been found that a compound of the general formula (I) having an isoxazole skeleton has excellent inhibitory activity against mutant IDH1 protein and inhibits the production of 2-HG by this protein, while the compound is also capable of effectively inhibiting the growth of various tumors expressing the protein. In the formula, R1, R2, R3, Y, and Z are as defined in claim 1.

Reformatsky and Blaise reactions in flow as a tool for drug discovery. One pot diversity oriented synthesis of valuable intermediates and heterocycles

The application of Reformatsky and Blaise reactions for the preparation of a diverse set of valuable intermediates and heterocycles in a one-pot protocol is described. To achieve this goal, a greener activation protocol for zinc in flow conditions has been developed to introduce this metal efficiently into α-bromoacetates. The organozinc compounds were added to a diverse set of ketones and nitriles to obtain a wide range of functional groups and heterocyclic systems.

PRODUCTION PROCESS OF 2,3'-BIPYRIDYL-6'-ONE

A production process where 2,3′-bipyridyl-6′-one can be produced in high purity at low cost on an industrial scale without using an expensive catalyst or special equipment is provided. A process for producing 2,3′-bipyridyl-6′-one comprises reacting an acetylpyridine derivative with at least one of compounds represented by formulae (II) to (V) to synthesize a bipyridine derivative and hydrolyzing the bipyridine derivative by one-pot preparation. In formulae (II) to (V), each of R2 to R8, X and Y represents a given group.

PROCESS FOR PRODUCTION OF 2,3'-BIPYRIDYL-6'-ONE

A production process where 2,3'-bipyridyl-6'-one can be produced in high purity at low cost on an industrial scale without using an expensive catalyst or special equipment is provided. A process for producing 2,3'-bipyridyl-6'-one comprises reacting an acetylpyridine derivative with at least one of compounds represented by formulae (II) to (V) to synthesize a bipyridine derivative and hydrolyzing the bipyridine derivative by one-pot preparation. In formulae (II) to (V), each of R2 to R8, X and Y represents a given group.

ANTIVIRAL AGENTS

The present invention is directed to compounds that are antiviral agents. Specificially the compounds of the present invention inhibit replication of HCV and are therefore useful in treating hepatitis C infections. The present invention is also directed t

Simple synthesis of (±)-epibatidine

Concise synthesis of racemic epibatidine (1), a non-opioid analgesic alkaloid, was accomplished starting from 6-chloropyridyl-3-carbaldehyde (6) via Robinson annulation for the construction of the skeleton, by introduction of amino group through Curtius r