216321-55-0Relevant academic research and scientific papers
As neuraminidase inhibitor compound and its use in medicine
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Paragraph 0179; 0182; 0186; 0187, (2018/02/04)
The invention discloses a compound serving as a neuraminidase inhibitor and application of the compound in a medicament and relates to a four-membered ring compound, application of the four-membered ring compound in a medicament and especially application of the four-membered ring compound in the medicament for preventing, treating, curing or alleviating an influenza virus disease. The compound has good action of inhibiting neuraminidase of influenza viruses. Particularly, the invention relates to a compound shown in a general formula (I) or a stereoisomer, a geometric isomer, a tautomer, nitrogen oxide, a hydrate, a solvate, a metabolite and a pharmaceuticallyacceptable salt or prodrug of the compound shown in the general formula (I), wherein all the variables are defined as a specification. The invention also relates to a medicament composition containing the compound shown in the general formula (I) and a method of treating an influenza disease by using the compound shown in the general formula (I) or the medicament composition of the compound. The formula is shown in the specification.
