2678-54-8 Usage
Description
Ketene diethyl acetal, also known as 1,1-diethoxyethylene, is an organic compound that serves as a versatile intermediate in various chemical reactions. It is characterized by its ability to participate in a range of chemical processes, making it a valuable component in both laboratory research and chemical production.
Uses
Used in Organic Synthesis:
Ketene diethyl acetal is used as an organic synthesis intermediate for its ability to engage in various chemical reactions, facilitating the creation of a wide array of organic compounds.
Used in Pharmaceutical Industry:
In the pharmaceutical sector, ketene diethyl acetal is utilized as a pharmaceutical intermediate. Its reactivity and capacity to form different chemical structures make it instrumental in the development of new drugs and medicinal compounds.
Used in Laboratory Research and Development:
Ketene diethyl acetal is employed in laboratory research and development processes, where its unique properties are harnessed to explore new chemical pathways and synthesize novel compounds for potential applications in various fields.
Used in Chemical Production Process:
KETENE DIETHYL ACETAL is also used in the chemical production process, where it contributes to the synthesis of a variety of chemical products, highlighting its importance in the chemical industry.
Synthesis
Preparation of 1,1-diethoxyethene 610.4 g (4.0 mol) of chloroacetaldehyde diethyl acetal, 800 g (12.0 mol) of powdered technical grade potassium hydroxide, 32 g of polyethylene glycol 1000 dimethyl ether and 88 g (1.0 mol) of 2-methyl-2-butanol were heated to reflux in 1.2 l of tert.-butyl methyl ether while stirring. After six hours the reaction was stopped, the salts filtered off and the reaction mixture distilled at reduced pressure (5 kPa). 326 g (72.5% of theoretical) of 1,1-diethoxyethene (b.p. 49° C./5 kPa) were obtained.
Check Digit Verification of cas no
The CAS Registry Mumber 2678-54-8 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 2,6,7 and 8 respectively; the second part has 2 digits, 5 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 2678-54:
(6*2)+(5*6)+(4*7)+(3*8)+(2*5)+(1*4)=108
108 % 10 = 8
So 2678-54-8 is a valid CAS Registry Number.
InChI:InChI=1/C6H12O2/c1-4-7-6(3)8-5-2/h3-5H2,1-2H3
2678-54-8Relevant articles and documents
Fields,D.L. et al.
, p. 390 - 395 (1968)
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Fukuda,M. et al.
, p. 2103 - 2105 (1975)
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Photoinduced Cross-Coupling of Aryl Iodides with Alkenes
Liu, Yuliang,Li, Haoyu,Chiba, Shunsuke
supporting information, p. 427 - 432 (2021/01/26)
A protocol for photoinduced cross-coupling of aryl iodides having polar π-functional groups or elongated π-conjugation with alkenes has been developed. The radical cascade mechanism involving generation of aryl radicals via C-I bond homolysis of photoexcited aryl iodides and their subsequent addition to alkenes is proposed. The method enables iodide-selective cross-coupling over other halogen leaving groups with functional group compatibility on both arene and alkene motifs.
Design, Synthesis, and Evaluation of a Series of Novel Benzocyclobutene Derivatives as General Anesthetics
Zhang, Chen,Li, Fangqiong,Yu, Yan,Huang, Anbang,He, Ping,Lei, Ming,Wang, Jianmin,Huang, Longbin,Liu, Zhenhong,Liu, Jianyu,Wei, Yonggang
supporting information, p. 3618 - 3625 (2017/05/19)
In the present work, a series of structurally novel benzocyclobutene derivatives were identified as general anesthetics through the loss of righting reflex (LORR) experiment on mice. Our initial efforts found compound 1a with a fused four-membered ring on the 2,3-position of the phenol ring could significantly improve the safety profile. Further SAR study revealed that small hydrogen bond acceptor (HBA) groups are optimal for good ED50 along with much broader therapeutic windows, such as compounds 16b and 17. Present work demonstrates the superiority of this novel benzocyclobutene scaffold.
Process for the synthesis of 3,4-dimethoxybicyclo[4.2.0]OCTA-1,3,5-triene-7-carbonitrile, and application in the synthesis of ivabradine and addition salts thereof with a pharmaceutically acceptable acid
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Page/Page column 5; 6, (2014/10/29)
Process for the synthesis of the compound of formula (I): Application in the synthesis of ivabradine, addition salts thereof with a pharmaceutically acceptable acid and hydrates thereof.