132294-22-5

Usage

Stereoisomer

1,2-cyclobutanedimethanol,3,3-diethoxy-,(1S-trans)-(9CI)
It is a stereoisomer of the mentioned compound, having the same molecular formula but a different spatial arrangement of atoms.

Derivative

Cyclobutane
The compound is derived from cyclobutane, a four-membered cyclic hydrocarbon.

Functional groups

Two methanol and two diethoxy groups
The compound contains two methanol (alcohol) groups and two diethoxy (ether) groups.

Application

Organic synthesis and pharmaceuticals
It is commonly used in organic synthesis and as a building block for the preparation of various pharmaceuticals and fine chemicals.

Physical state

Colorless liquid
The compound appears as a colorless liquid at room temperature.

Molecular weight

204.26 g/mol
The molecular weight of the compound is 204.26 grams per mole.

Boiling point

220-221°C at 760 mmHg
The compound boils at a temperature range of 220-221°C under a pressure of 760 mmHg (standard atmospheric pressure).

Upstream product

• 127696-10-0 trans-3,3-diethoxy-1,2-cyclobutanedicarboxylic acid diethyl ester 
• 216321-55-0 (1R,2S)-3,3-diethoxycyclobutane-1,2-dicarboxylic acid methyl ester 
• 2678-54-8 ketene diethyl acetal 
• 2032-35-1 Bromoacetaldehyde diethyl acetal 
• 132294-21-4 <1R-<1α(R^*),2β(R^*)>>-3,3-diethoxy-N,N'-bis-(2-hydroxy-1-phenylethyl)-1,2-cyclobutanedicarboxamide 
• 132294-29-2 (1R,2S)-3,3-Diethoxy-cyclobutane-1,2-dicarboxylic acid bis-{[(R)-2-(tert-butyl-dimethyl-silanyloxy)-1-phenyl-ethyl]-amide} 
• 132178-71-3 trans-3,3-diethoxy-1,2-cyclobutanedicarboxylic acid 
• 132294-30-5 C₃₈H₆₀N₄O₈Si₂ 

Downstream Products

• 139744-48-2 trans-3,3-diethoxy-1,2-bis<(benzyloxy)methyl>cyclobutane 
• 126261-73-2 C₂₀H₂₀O₅ 
• 124770-80-5 trans-2,3-bis(benzoyloxymethyl)cyclobutanone 
• 142343-73-5 (+/-)-(1α,2α,3β)-2,3-bis<(benzyloxy)methyl>cyclobutanol 
• 142434-69-3 (+)-(1S,2S,3S)-2,3-bis<(benzyloxy)methyl>-1-cyclobutanol 
• 142343-73-5 (-)-(1R,2R,3R)-2,3-bis<(benzyloxy)methyl>-1-cyclobutanol 
• 142343-78-0 (+)-(1R,2S,3S)-2-amino-7-<2,3-bis<(benzyloxy)methyl>cyclobutyl>pyrrolo<2,3-d>-pyrimidin-4(3H)-one 
• 142343-77-9 (+)-(1R,2S,3S)-2-amino-7-<2,3-bis<(benzyloxy)methyl>cyclobutyl>-4-chloropyrrolo<2,3-d>-pyrimidine 
• 142343-74-6 (+)-(1S,2S,3S)-2,3-bis<(benzyloxy)methyl>-1-cyclobutyl tosylate 
• 142343-75-7 C₂₀H₂₃N₃O₂ 
• 142343-72-4 (+)-(1S,2S,3S)-2,3-bis<(benzyloxy)methyl>-1-cyclobutyl acetate 
• 132164-72-8 trans-2,3-bis<(benzyloxy)methyl>cyclobutanone 
• 142343-76-8 (+)-(1R,2S,3S)-2,3-bis<(benzyloxy)methyl>cyclobutylamine 

Relevant academic research and scientific papers

CYCLOBUTYL NUCLEOSIDE ANALOGS AS ANTI-VIRALS

Described herein are cyclobutyl nucleoside analogs of Formula (I), pharmaceutical compositions that include one or more cyclobutyl nucleoside analogs and methods of using the same to treat HBV, HDV and/or HIV.

As neuraminidase inhibitor compound and its use in medicine

The invention discloses a compound serving as a neuraminidase inhibitor and application of the compound in a medicament and relates to a four-membered ring compound, application of the four-membered ring compound in a medicament and especially application of the four-membered ring compound in the medicament for preventing, treating, curing or alleviating an influenza virus disease. The compound has good action of inhibiting neuraminidase of influenza viruses. Particularly, the invention relates to a compound shown in a general formula (I) or a stereoisomer, a geometric isomer, a tautomer, nitrogen oxide, a hydrate, a solvate, a metabolite and a pharmaceuticallyacceptable salt or prodrug of the compound shown in the general formula (I), wherein all the variables are defined as a specification. The invention also relates to a medicament composition containing the compound shown in the general formula (I) and a method of treating an influenza disease by using the compound shown in the general formula (I) or the medicament composition of the compound. The formula is shown in the specification.

Synthetic studies toward providencin: Efficient construction of a furanyl-cyclobutanone fragment

Described is the construction of a furanyl-cylcobutanone fragment suited for incorporation into a synthesis of the naturally occurring anti-cancer agent Providencin.

Synthesis and antiviral activity of enantiomeric forms of cyclobutyl nucleoside analogues

The syntheses of the enantiomeric cyclobutyl guanine nucleoside analogues [1R-1α,2β,3α]- and [1S-1α,2β,3α]-2-amino-9-[2,3-bis(hydroxymethyl) cyclobutyl]-6H-purin-6-one (7 and 8, respectively) and the enantiomeric cyclobutyl adenine analogues [1R-1α,2β,3α]

Synthesis of SQ-33,054, a novel cyclobutane nucleoside with potent antiviral activity

The racemic, guanine-containing cyclobutane nucleoside SQ-33,054 (3) was synthesized in 8 steps from the cyclobutane diester 4.