2164-42-3Relevant academic research and scientific papers
Nickel-Catalyzed Reduction of Secondary and Tertiary Amides
Simmons, Bryan J.,Hoffmann, Marie,Hwang, Jaeyeon,Jackl, Moritz K.,Garg, Neil K.
supporting information, p. 1910 - 1913 (2017/04/11)
The nickel-catalyzed reduction of secondary and tertiary amides to give amine products is reported. The transformation is tolerant of extensive variation with respect to the amide substrate, proceeds in the presence of esters and epimerizable stereocenters, and can be used to achieve the reduction of lactams. Moreover, this methodology provides a simple tactic for accessing medicinally relevant α-deuterated amines.
Some potential α-adrenoreceptor blocking 1,4-benzodioxanes and 2,6-dimethoxyphenoxyethylamines
Dewar,Kapur,Mottram
, p. 286 - 290 (2007/10/02)
The synthesis and α-adrenoreceptor blocking activity of a series of 1,4-benzodioxanes and 2,6-dimethoxyphenoxyethylamines has been described. A number of analogues exhibited α-blockade, but none approached the potency of the benzodioxane WB 4101. Some mem
