216507-82-3Relevant academic research and scientific papers
Dihydropyridine neuropeptide Y Y1 receptor antagonists 2: Bioisosteric urea replacements
Poindexter, Graham S.,Bruce, Marc A.,Breitenbucher, J. Guy,Higgins, Mendi A.,Sit,Romine, Jeffrey L.,Martin, Scott W.,Ward, Sally A.,McGovern, Rachel T.,Clarke, Wendy,Russell, John,Antal-Zimanyi, Ildiko
, p. 507 - 521 (2007/10/03)
Structure-activity studies around the urea linkage in BMS-193885 (4a) identified the cyanoguanidine moiety as an effective urea replacement in a series of dihydropyridine NPY Y1 receptor antagonists. In comparison to urea 4a (Ki=3.3
DIHYDROPYRIDINE NPY ANTAGONISTS: CYANOGUANIDINE DERIVATIVES
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, (2008/06/13)
A series of non-peptidergic antagonists of NPY have been synthesized and are comprised of cyanoguanidine derivatives of 4-phenyl-1,4-dihydropyridines of Formula (I). STR1 As antagonists of NPY-induced feeding behavior, these compounds are expected to act
