21652-57-3Relevant academic research and scientific papers
Syntheses and properties of fluorous quaternary phosphonium salts that bear four ponytails; new candidates for phase transfer catalysts and ionic liquids
Emnet, Charlotte,Weber, Kathleen M.,Vidal, Jose A.,Consorti, Crestina S.,Stuart, Alison M.,Gladysz
, p. 1625 - 1634 (2006)
The fluorous tertiary phosphine [Rf6-(CH2) 2]3P [Rfn = CF3(CF2) n-1] and excess PhCH2Br, CH3(CH 2)3OSO2CF3
Ionic transformations in extremely nonpolar fluorous media: Phase transfer catalysis of halide substitution reactions
Consorti, Crestina S.,Jurisch, Markus,Gladysz, John A.
, p. 2309 - 2312 (2008/02/05)
Fluorous solutions of alkyl halides R18(CH2) mX (m = 2, 3; X = Cl, Br, I) are inert toward solid or aqueous NaCl, NaBr, and Kl, but halide substitution occurs in the presence of fluorous phosphonium salts (10 mol %, 76-100 °C).
Combining lipase-catalyzed enantiomer-selective acylation with fluorous phase labeling: A new method for the resolution of racemic alcohols
Hungerhoff, Benno,Sonnenschein, Helmut,Theil, Fritz
, p. 1781 - 1785 (2007/10/03)
Lipase-catalyzed acylation of racemic alcohols with a highly fluorinated acyl donor allows their kinetic resolution accompanied by the simultaneous enantiomer-selective fluorous phase labeling. Both the tagged and the untagged enantiomer can be separated without chromatography by a very efficient partition between a fluorous and an organic phase. The method has been successfully applied to the resolution of typically racemic secondary alcohols of low molecular weight. The fluorous label can be recovered quantitatively.
Separation of enantiomers by extraction based on lipase-catalyzed enantiomer-selective fluorous-phase labeling
Hungerhoff, Benno,Sonnenschein, Helmut,Theil, Fritz
, p. 2492 - 2494 (2007/10/03)
No chromatography is necessary to separate a racemic alcohol into its enantiomers. A highly fluorinated acyl residue was tranferred in an enantiomer-selective manner onto a racemic alcohol in the presence of a lipase [Eq. (1)]. The labeled enantiomer was separated from the unlabeled one by a simple but very efficient partition between fluorous and organic phases.
