216663-58-0Relevant academic research and scientific papers
Practical synthesis of tetrasubstituted thiophenes for use in compound libraries
McKibben, Bryan P.,Cartwright, Craig H.,Castelhano, Arlindo L.
, p. 5471 - 5474 (1999)
Tetrasubstituted thiophenes, obtained by optimizing the multi-component reaction originally developed by Gewald, served as key templates for structural diversification and semi-automated library synthesis. Conditions were developed to carry out Gewald's reaction at room temperature and in high yield.
