Tetrahedron Letters p. 5471 - 5474 (1999)
Update date:2022-08-04
Topics:
McKibben, Bryan P.
Cartwright, Craig H.
Castelhano, Arlindo L.
Tetrasubstituted thiophenes, obtained by optimizing the multi-component reaction originally developed by Gewald, served as key templates for structural diversification and semi-automated library synthesis. Conditions were developed to carry out Gewald's reaction at room temperature and in high yield.
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