21674-96-4

Usage

Uses

4-(4-Acetamidophenyl)-2-aminothiazole is a useful intermediate for organic synthesis.

InChI:InChI=1/C11H11N3OS/c1-7(15)13-9-4-2-8(3-5-9)10-6-16-11(12)14-10/h2-6H,1H3,(H2,12,14)(H,13,15)

Upstream product

• 21675-02-5 4-acetylaminophenacyl bromide 
• 17356-08-0 thiourea 
• 140-49-8 N-[4-(chloroacetyl)phenyl]acetamide 
• 103-84-4 Acetanilid 
• 2719-21-3 4-(N-acetylamino)acetophenone 
• 3673-53-8 2-amino-4-(4-amino-phenyl)-thiazole 
• 108-24-7 acetic anhydride 
• 99-81-0 4-Nitrophenacyl bromide 
• 2104-09-8 4-(4-nitro-phenyl)-thiazol-2-ylamine 

Downstream Products

• 105492-79-3 N-{4-[2-(7-Chloro-quinolin-4-ylamino)-thiazol-4-yl]-phenyl}-acetamide 
• 85849-67-8 N-[4-(4-Acetylamino-phenyl)-thiazol-2-yl]-oxalamic acid ethyl ester 
• 160315-35-5 2-<4'-(4''-acetamidophenyl)thiazol-2'-ylamino>-4,6-dichloro-s-triazine 
• 105492-87-3 4-<4-(4-aminophenyl)-2-thiazolylamino>-7-chloroquinoline 
• 105492-92-0 7-chloro-4-<4-(4-isothiocyanatophenyl)-2-thiazolylamino>quinoline 
• 105492-83-9 {4-[2-(7-Chloro-quinolin-4-ylamino)-thiazol-4-yl]-phenyl}-carbamic acid methyl ester 
• 105492-84-0 {4-[2-(7-Chloro-quinolin-4-ylamino)-thiazol-4-yl]-phenyl}-carbamic acid ethyl ester 
• 376349-93-8 N-[4-(2-{[(4-Bromo-5-chloro-thien-2-yl)sulfonyl]amino}-1,3-thiazol-4-yl)phenyl]acetamide 
• 376349-22-3 N-[4-(2-{[(4-propylphenyl)sulfonyl]amino}-1,3-thiazol-4-yl)phenyl]acetamide 
• 376349-66-5 N-[4-(2-{[(4-Bromo-2,5-difluorophenyl)sulfonyl]amino}-1,3-thiazol-4-yl)phenyl]acetamide 
• 376349-33-6 N-[4-(2-{[(3-chloro-2-methylphenyl)sulfonyl]amino}-1,3-thiazol-4-yl)phenyl]acetamide 
• 376349-73-4 N-[4-(2-{[(2,4,5-Trichlorophenyl)sulfonyl]amino}-1,3-thiazol-4-yl)phenyl]acetamide 
• 376349-39-2 N-[4-(2-{[(2,4,6-trichlorophenyl)sulfonyl]amino}-1,3-thiazol-4-yl)phenyl]acetamide 
• 376349-51-8 N-[4-(2-{[(2,4-dichloro-6-methylphenyl)sulfonyl]amino}-1,3-thiazol-4-yl)phenyl]acetamide 

Relevant academic research and scientific papers

COMPOSITIONS AND METHODS OF TARGETING MUTANT K-RAS

Compounds and compositions are presented that inhibit K-ras, and especially mutant K-ras. Certain compounds preferentially or even selectively inhibit specific forms of mutant K-Ras, and particularly the G12D mutant form.

NOVEL AZO COMPOUND, AQUEOUS SOLUTION, INK COMPOSITION, INK FOR INKJET RECORDING, INKJET RECORDING METHOD, INK CARTRIDGE FOR INKJET RECORDING AND INKJET RECORDING

The present invention relates to an aqueous solution and an ink composition, which can provide a stable ink which has a good hue as black ink, imparts colored images or colored materials having an excellent fastness, and furthermore, has a small change in physical properties, particularly suppressed bronzing even when preserved over a long period of time. In addition, there is provided a method of forming an image, which provides ink for printing or recording, such as inkjet, and prevents a reduction in image quality of the formed image (a method of preventing a reduction in image quality). An aqueous solution containing (a) a preservative and (b) at least one azo compound represented by the following Formula (1) or a salt thereof, in which the content of (b) is 1% by mass to 25% by mass. (In Formula (1), G represents a nitrogen atom or -C(R2)=. R2 represents a hydrogen atom, a sulfo group, a carboxyl group, a substituted or unsubstituted carbamoyl group or a cyano group. X1, X2, X3, X4, X5, X6 and X7 each independently represents a hydrogen atom or a monovalent substituent. Y2, Y3 and Y4 each independently represents a hydrogen atom or a monovalent substituent. Y2, Y3 and Y4 may be bonded with each other to form a ring. All of Y2, Y3 and Y4 do not represent hydrogen atoms at the same time. M each independently represents a hydrogen atom or a monovalent countercation.)

NOVEL AZO COMPOUND, AQUEOUS SOLUTION, INK COMPOSITION, INK FOR INKJET RECORDING, INKJET RECORDING METHOD, INK CARTRIDGE FOR INKJET RECORDING AND INKJET RECORDING

Provided is an aqueous solution and an ink composition having a favorable color as black ink, providing a colored image or a colored material having excellent fastness by removing a change in image quality of a record by a difference in recording paper, and providing stable ink having a small change in physical properties, particularly, suppressed bronze gloss, even though preservation is performed over a long period of time. In addition, there is provided a method of forming an image, which provides ink for printing or recording, such as inkjet, and prevents a reduction in image quality of the formed image (a method of preventing a reduction in image quality). An aqueous solution including: (a) a preservative, and (b) at least one kind of an azo compound represented by the following Formula (1) or a salt thereof, wherein a content of (b) is 1% by mass to 25% by mass: wherein, in Formula (1), A represents a substituted phenyl group or a substituted or unsubstituted nitrogen-containing 5-membered heterocyclic group, G represents a nitrogen atom or -C(R2)=, R2 represents a hydrogen atom, a sulfo group, a carboxy group, a substituted or unsubstituted carbamoyl group or cyano group, Y2, Y3 and Y4 each independently represents a hydrogen atom or a monovalent substituent, Y2, Y3 and Y4 may be bonded to each other to form a ring, all of Y2, Y3 and Y4 do not represent a hydrogen atom at the same time, and M each independently represents a hydrogen atom or a monovalent countercation.

UREA DERIVATIVES METHODS FOR THEIR MANUFACTURE AND USES THEREOF

The present invention provides compounds of formula (I): in which R 1, R'1, R2, R'2, R3, Y and G have the meanings given in the description, to a process for their preparation, their application by way of medicaments, and to pharmaceutical compositions containing them.

SUBSTITUTED QUINAZOLINE DERIVATIVES AND THEIR USE AS INHIBITORS

The use of a compound of formula (I) 1 or a salt, ester or amide thereof; where X is O, or S, S(O) or S(O)2, or NR6 where R6 is hydrogen or C1-6 alkyl,; R5 is an optionally substituted 5-membered heteroaromatic ring, R1, R2 ,R3, R4 are independently selected from various specified moieties, in the preparation of a medicament for use in the inhibition of aurora 2 kinase. Certain compounds are novel and these, together with pharmaceutical compositions containing them are also described and claimed

N-(4-Substituted-thiazolyl)oxamic Acid Derivatives, a New Series of Potent, Orally Actve Antiallergy Agents

A series of N-(4-substituted-thiazolyl)oxamic acid derivatives were synthesized and tested for antiallergy activity in the rat PCA model.These compounds were conveniently prepared by treatment of the appropriate acetophenone with thiourea and iodine or by reaction of the chloroacetylbenzene with thiourea to give the corresponding aminothiazoles; subsequent condensation with ethyloxalyl chloride gave the thiazolyloxamates.Many of the analogues showed a 50percent inhibition at oxamic acid ethanolamine salt (61, PRH-836-EA), has been selected for further pharmacological evaluation.