21675-02-5

Basic information

• Product Name: AKOS BBS-00004805
• Synonyms: BUTTPARK 48\12-82;AKOS BBS-00004805;N-[4-(2-BROMO-ACETYL)-PHENYL]-ACETAMIDE;AcetaMide, N-[4-(2-broMoacetyl)phenyl]-;4-Acetamidophenacyl bromide;N-[4-(Bromoacetyl)phenyl]acetamide, 4'-(Bromoacetyl)acetanilide
• CAS NO: 21675-02-5
• Molecular Formula: C₁₀H₁₀BrNO₂
• Molecular Weight: 256.1
• Mol File: 21675-02-5.mol
• Article Data: 18

Chemical Properties

• Boiling Point: 433.168 °C at 760 mmHg
• Flash Point: 215.773 °C
• Appearance: /
• Density: 1.531
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: AKOS BBS-00004805(CAS DataBase Reference)
• NIST Chemistry Reference: AKOS BBS-00004805(21675-02-5)
• EPA Substance Registry System: AKOS BBS-00004805(21675-02-5)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 21675-02-5(Hazardous Substances Data)

Usage

General Description

AKOS BBS-00004805 is a chemical compound with the molecular formula C27H31NO. It is a member of the benzylisoquinoline alkaloid family, which are natural products found in various plants. AKOS BBS-00004805 is commonly used in medicinal chemistry and drug discovery research for its potential therapeutic properties. However, further studies are needed to fully understand its biological activity and potential applications. Overall, AKOS BBS-00004805 is a promising chemical compound with the potential for various pharmaceutical and medical applications.

Upstream product

• 2719-21-3 4-(N-acetylamino)acetophenone 
• 51-79-6 urethane 
• 99-92-3 p-aminobenzophenone 
• 598-21-0 2-Bromoacetyl bromide 
• 103-84-4 Acetanilid 

Downstream Products

• 77281-09-5 1-(4-acetylamino-phenacyl)-pyridinium; bromide 
• 65321-91-7 N-[4-(2-methyl-4-thiazolyl)phenyl]acetamide 
• 188119-60-0 4-acetamidophenacyl dibenzyl phosphate 
• 857951-83-8 2-(4-acetamidophenyl)-2-oxoethyl acetate 
• 566949-35-7 N-[4-(2-bromo-1-hydroxyethyl)phenyl]acetamide 
• 543739-85-1 N-(4-{2-[(2,4-dichloro-benzyl)-methyl-amino]-acetyl}-phenyl)-acetamide 

Relevant articles and documents

Novel Aryl-Substituted Pyrimidones as Inhibitors of 3-Mercaptopyruvate Sulfurtransferase with Antiproliferative Efficacy in Colon Cancer

The enzyme 3-mercaptopyruvate sulfurtransferase (3-MST) is one of the more recently identified mammalian sources of H2S. A recent study identified several novel 3-MST inhibitors with micromolar potency. Among those, (2-[(4-hydroxy-6-methylpyrimidin-2-yl)sulfanyl]-1-(naphthalen-1-yl)ethan-1-one) or HMPSNE was found to be the most potent and selective. We now took the central core of this compound and modified the pyrimidone and the arylketone sides independently. A 63-compound library was synthesized; compounds were tested for H2S generation from recombinant 3-MST in vitro. Active compounds were subsequently tested to elucidate their potency and selectivity. Computer modeling studies have delineated some of the key structural features necessary for binding to the 3-MST's active site. Six novel 3-MST inhibitors were tested in cell-based assays: they exerted inhibitory effects in murine MC38 and CT26 colon cancer cell proliferation; the antiproliferative effect of the compound with the highest potency and best cell-based activity (1b) was also confirmed on the growth of MC38 tumors in mice.

INHIBITORS OF HISTONE DEACETYLASE

This invention provides compounds that are inhibitors of HDAC2. The compounds (e.g., compounds according to Formula (I), (II), (IIa), (III), (IV), (V), or (VI)) accordingly are useful for treating, alleviating, or preventing a condition in a subject such as a neurological disorder, memory or cognitive function disorder or impairment, extinction learning disorder, fungal disease or infection, inflammatory disease, hematological disease, or neoplastic disease, or for improving memory or treating, alleviating, or preventing memory loss or impairment.

Synthesis and anticancer activity evaluation of N-[4-(2-methylthiazol-4-yl) phenyl]acetamide derivatives containing (benz)azole moiety

A new class of novel thiazole-(benz)azole derivatives was synthesized to investigate their anticancer activity. The structure of the compounds was confirmed by IR, 1H-NMR, and MS spectral data and elemental analyses. Anticancer effect of the compounds was evaluated against A549 and C6 tumor cell lines. MTT, analysis of DNA synthesis, acridine orange/ethidium bromide staining method and analysis of caspase-3 activation assays were performed for anticancer activity investigations. Compounds 6f and 6g, which carry 5-chloro and 5-methylbenzimidazole groups showed significant anticancer activity. Potential of these compounds to direct tumor cells to apoptotic pathway, which is a precondition of anticancer action, was also observed.