21675-25-2

Upstream product

• 3623-15-2 phenyl propargyl ketone 
• 98-88-4 benzoyl chloride 
• 13829-77-1 3-(trimethylsilyl)-1-phenyl-2-propyn-1-one 
• 4187-87-5 1-Phenyl-2-propyn-1-ol 
• 17338-03-3 1,6-diphenylhexa-2,4-diyne-1,6-diol 

Downstream Products

• 49571-81-5 2-morpholin-4-yl-1,6-diphenyl-hex-2-en-4-yne-1,6-dione 
• 79349-43-2 1,1',5,5'-tetraphenyl-3,3'-bipyrazole 
• 58884-07-4 2,5,2',5'-tetraphenyl-2H,2'H-[3,3']bipyrazolyl 

Relevant academic research and scientific papers

A facile copper(i)-catalyzed homocoupling of terminal alkynes to 1,3-diynes with diaziridinone under mild conditions

A novel and efficient Cu(i)-catalyzed oxidative homocoupling of terminal alkynes with diaziridinone as an oxidant is described. Various terminal alkynes can be transformed into the corresponding 1,3-diynes in good yields. The reaction process is base-free

Synthesis of linked heterocycles via use of bis-acetylenic compounds

Linked bis-pyrazoles, a pyrazolyl-isoxazole, a pyrazolyl-pyrimidine and a pyrazolyl-triazole were synthesized starting with commercially available 1,4-bis(trimethylsilyl)-1,3-butadiyne 1 or readily available bis-acetylenic diketone 22. A stepwise approach

Friedel-crafts reactions of bis(trimethylsilyl)polyynes with acyl chlorides; a useful route to terminal-alkynyl ketones

Bis(trimethylsilyl)acetylenes, Me3Si(CC)nSiMe3, react with acyl chloride-aluminium chloride complexes, XC6H4 COCl·AlCl3 in methylene chloride at 0-20° to form the corresponding ketones XC6H4CO(CC)nSiMe3 in excellent (n = 1) or moderate (n = 2, 4) yield. Treatment of the products with aqueous methanolic borax results in virtually quantitative liberation of the terminal alkynyl ketones XC6H4CO(CC)nH. The method provides the first practical route to the ketotetraynes (n = 4) and usefully supplements existing oxidative methods for keto-monoyne and -diyne synthesis. The oxalyl chloride-aluminium chloride complex reacts with Me3SiCCSiMe3 to give the novel silyl-substituted heterocycle (I): {A figure is presented}.