79349-43-2Relevant academic research and scientific papers
Synthesis of linked heterocycles via use of bis-acetylenic compounds
Smith, Christopher D.,Tchabanenko, Kirill,Adlington, Robert M.,Baldwin, Jack E.
, p. 3209 - 3212 (2007/10/03)
Linked bis-pyrazoles, a pyrazolyl-isoxazole, a pyrazolyl-pyrimidine and a pyrazolyl-triazole were synthesized starting with commercially available 1,4-bis(trimethylsilyl)-1,3-butadiyne 1 or readily available bis-acetylenic diketone 22. A stepwise approach
1,3,4,6-Tetracarbonyl compounds: IV. Reaction of 3,4-dihydroxy-2,4-hexadiene-1,6-diones with hydrazine and arylhydrazines
Shironina,Igidov,Koz'minykh,Kon'shina,Kasatkina,Koz'minykh
, p. 1486 - 1494 (2007/10/03)
Reactions of 1,6-disubstituted 3,4-dihydroxy-2,4-hexadiene-1,6-diones with hydrazine hydrate or hydrochloride afforded heterocyclization products, 3,3′-bipyrazoles. The chemoselective reaction of 1,6-diaryl-3,4-dihydroxy-2,4-hexadiene-1,6-diones with arylhydrazines gave rise to 1,1′,5,5′-tetraaryl-3,3′-bipyrazoles and 1 ,5-diaryl-3-aroylacetylpyrazoles. The specific structural features of the pyrazole derivatives obtained are discussed. Some pyrazoles show bacteriostatic and antileukemic activity.
